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Effects of the anti-androgen, bicalutamide, in a reduced life-cycle study with the fathead minnow (Pimephales promelas).
Author: GlennonY C, HargreavesA, Murray-SmithR, PanterG H, RobinsonJ
Original Abstract of the Article :
In support of the environmental risk assessment (ERA) of the non-steroidal anti-androgen bicalutamide, a reduced fish full life-cycle (FFLC) was conducted. The traditional FFLC is deemed to be the "gold standard" for evaluating the potential environmental impact of human pharmaceuticals, covering al...See full text at original site
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引用元:
https://doi.org/10.1016/j.aquatox.2012.02.002
データ提供:米国国立医学図書館(NLM)
Evaluating Environmental Risks: A Study of Bicalutamide
This research delves into the important field of environmental risk assessment, exploring the potential environmental impacts of bicalutamide, a non-steroidal anti-androgen drug used to treat prostate cancer. The study uses a reduced fish full life-cycle (FFLC) model, a streamlined approach to assessing the long-term effects of chemicals on fish. The study identified a significant decrease in nuptial tubercle prominence, a secondary sexual characteristic, in male fathead minnows exposed to high concentrations of bicalutamide. The study also observed reduced survival and reproductive success in the F1 generation at the highest concentration, highlighting the potential for bicalutamide to disrupt fish reproduction and development.Navigating the Desert of Environmental Impact
This research delves into the complex world of environmental toxicology, navigating the potential effects of pharmaceuticals on aquatic ecosystems. Imagine a vast desert, where every drop of water is precious. Similarly, the delicate balance of aquatic ecosystems is sensitive to the introduction of pollutants. This study highlights the importance of assessing the environmental impacts of pharmaceuticals, particularly those with potential endocrine disrupting effects, ensuring the protection of aquatic life.Protecting Aquatic Life: A Collective Responsibility
This study underscores the importance of environmental stewardship, particularly in the context of pharmaceuticals. As we develop and use pharmaceuticals, it is crucial to consider their potential effects on the environment. This research highlights the importance of careful assessment and mitigation strategies to minimize the risks associated with pharmaceutical pollution, ensuring the protection of aquatic ecosystems and the diverse life they support.Dr. Camel's Conclusion
This study provides valuable insights into the potential environmental impacts of bicalutamide. The study's findings suggest that high concentrations of bicalutamide can disrupt fish reproduction and development, highlighting the importance of carefully evaluating the environmental risks of pharmaceuticals. This research emphasizes the need for sustainable practices in pharmaceutical development and use, minimizing the potential for environmental pollution and protecting aquatic life.Date :
- Date Completed 2012-07-30
- Date Revised 2014-11-20
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