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Effects of a reduced dose of stavudine on the incidence and severity of peripheral neuropathy in HIV-infected adults in South Africa.

Author: GlesbyMarshall J, GroblerAnneke, GumedeSizwe, KarimFarina, NaidooKogieleum, PahujaMeera, ParkerGary

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study compared the incidence and severity of peripheral neuropathy in a retrospective cohort of patients receiving stavudine (d4T), an antiretroviral therapy, at different doses. The study aimed to assess the impact of a WHO-recommended dose reduction from 40 mg to 30 mg on d4T-associated toxicities.
Paper Details　
Original Abstract of the Article :
Although recent World Health Organization (WHO) guidelines recommend withdrawing stavudine (d4T) from first-line antiretroviral therapy (ART), it remains commonly used in resource-limited settings. In 2006, WHO recommended decreasing the dose of d4T from 40 mg to 30 mg to mitigate toxicities. We com...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/22414588

データ提供：米国国立医学図書館（NLM）

Stavudine: A Cautious Approach to HIV Treatment

The desert of HIV research is vast and constantly evolving. This study delves into the world of [HIV treatment] to examine the impact of stavudine (d4T), an antiretroviral medication, on the incidence and severity of peripheral neuropathy in HIV-infected adults. Researchers, like explorers seeking safer paths through a challenging landscape, investigated the effects of reducing the dosage of stavudine. Their findings suggest that reducing the dose of stavudine from 40 mg to 30 mg might help mitigate the risk of peripheral neuropathy, a common side effect of this medication. The researchers found that reducing the dose of stavudine from 40 mg to 30 mg was associated with a lower incidence and severity of peripheral neuropathy, providing valuable insights for managing this side effect.

Navigating the Terrain of HIV Treatment

The study highlights the importance of carefully managing the risks and benefits of antiretroviral medications. It suggests that reducing the dose of stavudine could be a beneficial strategy for minimizing the risk of peripheral neuropathy in HIV-infected patients. This research encourages continuous research to optimize HIV treatment strategies and minimize the risk of adverse effects.

Minimizing Side Effects in HIV Treatment

This research emphasizes the importance of minimizing side effects in HIV treatment. It highlights the potential benefits of adjusting medication dosages to reduce the risk of complications. The study underscores the importance of patient-centered care and the need to carefully consider the individual needs and risks of each patient.

Dr.Camel's Conclusion

This study, a journey through the complexities of HIV treatment, reveals the potential benefits of reducing the dose of stavudine to minimize the risk of peripheral neuropathy. It highlights the importance of continuous research to optimize treatment strategies and minimize adverse effects. This research serves as a reminder of the ongoing quest for safer and more effective treatments for HIV.

Date :
  1. Date Completed 2012-09-05
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22414588

DOI: Digital Object Identifier

NIHMS364739

Related Literature

Article Analysis
・Effects of stavudine
SNS
PICO Info
in preparation
Languages

English

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