Short-term (2-week) effects of discontinuing milnacipran in patients with fibromyalgia.

Author: ArnoldLesley M, ChenWei, GendreauR Michael, PalmerRobert H, SaxePhilippe A

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To examine the effects of abruptly withdrawing milnacipran during the 2-week discontinuation phase of a study in which FM patients had received 12 weeks of stable-dose treatment with milnacipran at 100 mg/day. RESEARCH DESIGN AND METHODS: The effects of withdrawing milnacipran were evalu...See full text at original site
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引用元:
https://doi.org/10.1185/03007995.2012.677418

データ提供:米国国立医学図書館(NLM)

Milnacipran: A Beacon in the Desert of Fibromyalgia

Fibromyalgia, a chronic condition characterized by widespread musculoskeletal pain, fatigue, and other symptoms, can feel like a relentless sandstorm, making it difficult to navigate daily life. This study explores the short-term effects of discontinuing milnacipran, a medication often used to treat fibromyalgia.

The researchers, like intrepid desert explorers, conducted a randomized, placebo-controlled withdrawal study involving patients who had received 12 weeks of stable-dose treatment with milnacipran. They randomly assigned patients to either continue milnacipran or switch to placebo for two weeks. They then monitored pain levels, functional status, and other measures to assess the impact of discontinuing milnacipran.

A Reminder of the Sandstorm's Power

The researchers found that patients who discontinued milnacipran, like a camel caravan abruptly encountering a sandstorm, experienced a significant worsening of pain, functional status, and global status measures within two weeks. This highlights the importance of maintaining a consistent treatment regimen for fibromyalgia.

Navigating the Sandstorms of Fibromyalgia

This study, like a guidebook for traveling through the desert, emphasizes the importance of careful management for fibromyalgia. It suggests that discontinuing milnacipran can lead to a rapid worsening of symptoms and that a consistent treatment plan is crucial for maintaining a good quality of life. It reminds us that the journey through fibromyalgia, like navigating a vast and unforgiving desert, requires dedication and vigilance.

Dr. Camel's Conclusion

This study serves as a reminder that fibromyalgia can be a persistent challenge, like a sandstorm that can quickly return once the wind shifts. Discontinuing milnacipran can lead to a rapid worsening of symptoms, highlighting the importance of maintaining a consistent treatment plan. It's a reminder that the journey through fibromyalgia, like navigating a vast and unforgiving desert, requires dedication and vigilance.

Date :
  1. Date Completed 2012-09-28
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

22429066

DOI: Digital Object Identifier

10.1185/03007995.2012.677418

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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