Publication bias in antipsychotic trials: an analysis of efficacy comparing the published literature to the US Food and Drug Administration database.

Author: KnoepflmacherDaniel, ShapleyLee, TurnerErick H

Paper Details 
Original Abstract of the Article :
Publication bias compromises the validity of evidence-based medicine, yet a growing body of research shows that this problem is widespread. Efficacy data from drug regulatory agencies, e.g., the US Food and Drug Administration (FDA), can serve as a benchmark or control against which data in journal ...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308934/

データ提供:米国国立医学図書館(NLM)

Publication Bias: A Mirage in the Desert of Medical Research

Publication bias, a phenomenon where studies with positive results are more likely to be published than those with negative results, can distort our understanding of medical research. This study investigates the extent of publication bias in antipsychotic drug trials by comparing data published in journals with data from the US Food and Drug Administration (FDA) database. The researchers found that publication bias was present in antipsychotic trials, suggesting that published results may overestimate the effectiveness of these drugs.

Publication Bias in Antipsychotic Trials: A Need for Critical Evaluation

The study's findings highlight the importance of considering publication bias when evaluating medical research. It's crucial to be aware of the potential for bias and to critically evaluate published findings, especially when making decisions about treatment options.

Navigating Medical Information: A Guide for Consumers

It's important to approach medical information with a critical eye, recognizing the potential for bias. Consult with your doctor and consider a range of sources when making decisions about your health.

Dr. Camel's Conclusion

Publication bias can be like a mirage in the desert of medical research, creating an illusion of effectiveness that might not reflect the true picture. This study emphasizes the need for vigilance in evaluating medical literature, ensuring that our understanding of treatment options is based on accurate and unbiased evidence.

Date :
  1. Date Completed 2012-07-16
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22448149

DOI: Digital Object Identifier

PMC3308934

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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