Relapse and disability outcomes in patients with multiple sclerosis treated with fingolimod: subgroup analyses of the double-blind, randomised, placebo-controlled FREEDOMS study.

Author: , AgoropoulouCatherine, DevonshireVirginia, FrancisGordon, HavrdovaEva, HäringDieter Adrian, KapposLudwig, O'ConnorPaul, RadueErnst Wilhelm, Zhang-AubersonLixin

Paper Details 
Original Abstract of the Article :
Fingolimod 0·5 mg once daily is approved for treatment of relapsing multiple sclerosis (MS). In the phase 3, 2-year FREEDOMS (FTY720 Research Evaluating Effects of Daily Oral therapy in MS) study, fingolimod significantly reduced annualised relapse rates (ARRs) and the risk of confirmed disability p...See full text at original site
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引用元:
https://doi.org/10.1016/S1474-4422(12)70056-X

データ提供:米国国立医学図書館(NLM)

Fingolimod for Relapsing Multiple Sclerosis: A Deep Dive into Patient Subgroups

The field of [multiple sclerosis] research is constantly evolving, and we're always seeking new ways to treat this challenging condition. This study delves into the effectiveness of [fingolimod], a medication used to manage [relapsing multiple sclerosis]. The researchers utilized a [double-blind, randomised, placebo-controlled] approach, a gold standard in clinical trials, to investigate the impact of fingolimod on patients with varying baseline characteristics. They aimed to determine if the positive effects observed in the overall patient population held true for specific subgroups.

Subgroup Analysis: Uncovering Individualized Responses

The study uncovered interesting insights about the effectiveness of fingolimod. It revealed that the beneficial treatment effect observed in the overall population was consistent in subgroups of patients with different baseline characteristics. This suggests that fingolimod could be an effective treatment option for a wider range of patients, regardless of their individual traits.

Understanding the Nuances of Treatment

This study emphasizes the importance of individualizing treatment approaches for patients with [multiple sclerosis]. Each individual responds differently to medications, and understanding these nuances is crucial for optimizing treatment outcomes. The findings of this study provide valuable data for clinicians to personalize therapy based on patient-specific factors.

Dr. Camel's Conclusion

This study, much like a desert oasis, provides a refreshing perspective on the treatment of multiple sclerosis. It highlights the importance of tailored treatment approaches, reminding us that one size doesn't fit all, even in the vast landscape of medical research. By understanding the subtle differences between patient subgroups, we can pave the way for more effective and personalized treatment strategies.

Date :
  1. Date Completed 2012-06-06
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

22494956

DOI: Digital Object Identifier

10.1016/S1474-4422(12)70056-X

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English

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