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Negative electro-mechanical windows are required for drug-induced Torsades de Pointes in the anesthetized guinea pig.

Author: GunsP-J, JohnsonD M, LissensJ, WeltensE

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the behavior of a novel surrogate marker for Torsades de Pointes (TdP), the electro-mechanical (E-M) window, prior to triggering of TdP episodes with sympathetic stimulation after administration of a number of reference compounds. The E-M window is increasingly recognized as a more accurate predictor of TdP than QT prolongation alone.
Paper Details　
Original Abstract of the Article :
Assessment of the propensity of novel drugs to cause proarrhythmia is essential in the drug development process. It is increasingly recognized, however, that QT prolongation alone is an imperfect surrogate marker for Torsades de Pointes (TdP) arrhythmia prediction. In the present study we investigat...See full text at original site
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引用元：
https://doi.org/10.1016/j.vascn.2012.03.007

データ提供：米国国立医学図書館（NLM）

Unlocking the Secrets of Torsades de Pointes: A New Approach to Drug Safety

This [study] delves into the complex and potentially dangerous world of [drug-induced Torsades de Pointes (TdP)], a type of life-threatening heart arrhythmia. It's like exploring a hidden canyon in the desert of drug safety research, seeking to understand the mechanisms that can lead to this potentially fatal condition.

The authors investigated the role of [electro-mechanical (E-M) windows] in predicting TdP. Their research suggests that [negative E-M windows] are a critical factor in the development of TdP. This finding has important implications for the drug development process, as it provides a valuable tool for assessing the proarrhythmic potential of new drugs.

A Beacon in the Desert: Improving Drug Safety and Protecting Patients

This research offers a valuable tool for improving drug safety and protecting patients from the risk of TdP. By carefully evaluating [E-M windows] during drug development, researchers can identify potential proarrhythmic drugs and minimize the risk of patients experiencing this potentially fatal condition.

A Desert of Hope: Finding a Path to Safer Drugs

The study offers a beacon of hope in the desert of drug safety research, suggesting that by understanding the mechanisms of TdP, we can develop safer drugs and protect patients from this potentially life-threatening condition.

Dr. Camel's Conclusion

This research, like a compass in the desert of drug safety, points us toward a new approach to drug development, ensuring that we can navigate the risks and find the path to safer and more effective medications.

Date :
  1. Date Completed 2013-01-17
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

22516473

DOI: Digital Object Identifier

10.1016/j.vascn.2012.03.007

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