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Submicron-size biodegradable polymer-based didanosine particles for treating HIV at early stage: an in vitro study.

Author: BasakSandip, BeraTanmoy, GhoshSaikat, MondalSubhasish, MukherjeeBiswajit, PattnaikGurudutta, SinhaBiswadip

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study aimed to develop poly(d,l-lactic-co-glycolic acid)-based nanoparticles containing didanosine and to observe their uptake by macrophages in vitro.
Paper Details　
Original Abstract of the Article :
Human immunodeficiency viruses (HIV) hide themselves in macrophages at the early stage of infection. Delivering drug in a sustained manner from polymeric nanoparticles in those cells could control the disease effectively. The study was intended to develop poly(d,l-lactic-co-glycolic acid)-based nano...See full text at original site
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引用元：
https://doi.org/10.3109/02652048.2012.680509

データ提供：米国国立医学図書館（NLM）

Submicron-Size Didanosine Particles: A New Weapon Against HIV

This research explores innovative strategies for drug delivery in the fight against HIV infection. The study focuses on the development of submicron-sized biodegradable polymer-based didanosine particles, a novel approach aimed at delivering the antiviral drug didanosine in a sustained manner. The authors investigated the uptake of these particles by macrophages, cells that are known to harbor HIV in the early stages of infection. The study's findings suggest that these nanoparticles could effectively target macrophages, leading to sustained drug release and potentially improved control of early-stage HIV infection.

Nanotechnology in the Fight Against HIV

The study showcases the potential of nanotechnology to improve drug delivery and enhance treatment outcomes for HIV infection. This innovative approach holds promise for addressing the challenges of drug resistance and optimizing therapeutic strategies.

A Targeted Approach: Reaching the Hidden Enemy

Imagine a vast desert landscape, where HIV hides within the cells of the immune system. This study explores a new strategy for reaching these hidden enemies: nanoparticles that can deliver antiviral drugs directly to infected macrophages. This targeted approach offers the potential to combat HIV more effectively, potentially improving treatment outcomes and the lives of those living with this challenging disease.

Dr.Camel's Conclusion

This research explores the potential of submicron-sized didanosine particles for targeted drug delivery in the fight against HIV infection. The study suggests that these nanoparticles could effectively target macrophages, leading to sustained drug release and potentially improved control of early-stage HIV infection. This innovative approach holds promise for enhancing treatment outcomes and improving the lives of those living with HIV.

Date :
  1. Date Completed 2013-04-03
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

22545676

DOI: Digital Object Identifier

10.3109/02652048.2012.680509

Related Literature

Article Analysis
・Side Effects of didanosine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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