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Use of crossover trials to obtain antihypertensive dose-response curves and to study combination therapy during the development of benazepril.

Author: BelletM, BodinF, MénardJ, SerrurierD, TannerK, WhalenJ J

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Crossover trials were found to be useful for dose-determination studies of antihypertensive drugs. In the development of benazepril, a new ACE inhibitor, crossover trials were used to obtain reliable data and define the effects of the drug.
Paper Details　
Original Abstract of the Article :
When a new drug is developed, one of the first requirements is to establish the correct dose. Unfortunately, in dose-determination studies, not enough lessons have been learned from the past. Pilot studies are often planned without sufficient statistical power, due to an insufficient number of patie...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2258783

データ提供：米国国立医学図書館（NLM）

Dose Determination in Antihypertensive Drug Development: Lessons from Benazepril

Developing effective antihypertensive medications involves determining the optimal dose, which can be a complex and time-consuming process. This article, published in [Journal name], highlights the use of crossover trials in the development of the angiotensin-converting enzyme (ACE) inhibitor benazepril. The authors demonstrate how crossover trials can provide valuable information about a drug's dose-response relationship and its interaction with other medications. They emphasize that well-designed and statistically powered studies are essential for ensuring the efficient and successful development of new antihypertensive drugs.

The Power of Crossover Trials: Optimizing Antihypertensive Treatments

This article showcases the value of crossover trials in drug development. By carefully controlling for variables and minimizing bias, these trials provide more reliable data than traditional dose-determination studies. The use of crossover trials can lead to more precise dose recommendations, improving the efficacy and safety of antihypertensive medications.

Managing Hypertension: The Importance of Precision Dosing

This research highlights the importance of accurate dose determination in managing hypertension. Finding the right dose for each individual can optimize treatment efficacy while minimizing potential side effects. Working closely with your healthcare professional to monitor your blood pressure and adjust medication dosages as needed is crucial for maintaining optimal blood pressure control.

Dr.Camel's Conclusion

Just as a camel navigates the desert with precision and care, finding the right dose for an antihypertensive medication requires careful consideration. This article underscores the importance of using the right tools for the job, with crossover trials serving as a valuable compass in the quest for effective and safe blood pressure management.

Date :
  1. Date Completed 1991-01-31
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2258783

DOI: Digital Object Identifier

2258783

Related Literature

Article Analysis
・Side Effects of benazepril
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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