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Genotoxic effects of radiotherapy and chemotherapy on the circulating lymphocytes of breast cancer patients. III: Measurement of mutant frequency to 6-thioguanine resistance.

Author: ColeJ, GreenM H, MoustacchiE, RigaudO, Sala-TrepatM, VilcoqJ R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Radiation therapy was found to be the primary factor contributing to increased mutant frequencies in peripheral blood lymphocytes of breast cancer patients. In a study of breast cancer patients who received either local radiotherapy followed by chemotherapy or chemotherapy followed by radiotherapy, the increase in mutant frequencies could be attributed solely to the effects of radiation.
Paper Details　
Original Abstract of the Article :
The mutant frequencies (MF) at the HPRT locus of peripheral blood lymphocytes collected from breast cancer patients before and after treatment according to a defined protocol of the Institut Curie were compared to those from healthy donors. The treatment involved either a local radiotherapy (RT1) fo...See full text at original site
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引用元：
https://doi.org/10.1093/mutage/5.6.593

データ提供：米国国立医学図書館（NLM）

Genotoxic Effects of Cancer Treatment: A Study in Cellular Damage

This study, published in [Journal Name], examines the genotoxic effects of radiotherapy and chemotherapy on circulating lymphocytes in breast cancer patients. The researchers meticulously evaluate the mutant frequencies (MF) at the HPRT locus of peripheral blood lymphocytes before and after treatment, providing insights into the cellular damage caused by these therapies.

The Impact of Radiation on Lymphocyte Mutation

The study reveals that radiotherapy significantly increases the MF in circulating lymphocytes. This finding highlights the potential of radiation to induce genetic damage in these cells, underscoring the importance of minimizing radiation exposure and developing strategies to mitigate its genotoxic effects.

Protecting Cells from Treatment-Induced Damage

This research emphasizes the need for developing approaches to protect cells from the genotoxic effects of cancer therapies. By understanding the mechanisms of cellular damage, we can develop novel strategies to minimize side effects and improve patient outcomes.

Dr. Camel's Conclusion

This study reminds us that the battle against cancer often involves navigating a delicate balance between eradicating the disease and minimizing collateral damage. Just as a desert traveler seeks to minimize the risks of dehydration and exhaustion, we must strive to protect healthy cells while effectively targeting cancerous cells.

Date :
  1. Date Completed 1991-02-07
  2. Date Revised 2019-05-10
Further Info :

Pubmed ID

2263217

DOI: Digital Object Identifier

10.1093/mutage/5.6.593

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Article Analysis
・Effects of thioguanine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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