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Genetic variation in dopaminergic activity is associated with the risk for psychiatric side effects of levetiracetam.

Author: ElgerChristian E, HelmstaedterChristoph, HurlemannRené, KunzWolfram S, MihovYoan, NuernbergPeter, SchochSusanne, SurgesRainer, ThieleHolger, ToliatMohammad R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study aims to assess the genetic basis of irritability and aggression as side effects of levetiracetam (LEV) treatment. The study uses a candidate gene-based two-stage association study to identify potential genetic risk factors.
Paper Details　
Original Abstract of the Article :
Levetiracetam (LEV) is a highly effective antiepileptic agent. A clinically relevant psychiatric complication of LEV treatment, however, is the provocation of irritability and aggression. Recent behavioral research indicates that personality traits may predispose to these side effects. To assess the...See full text at original site
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引用元：
https://doi.org/10.1111/j.1528-1167.2012.03603.x

データ提供：米国国立医学図書館（NLM）

Levetiracetam: A Desert Oasis with Potential Side Effects

Levetiracetam, a widely used antiepileptic drug, is a beacon of hope for many patients with epilepsy. However, like a desert oasis that can be both refreshing and dangerous, levetiracetam can also come with potential side effects. This research investigates the genetic basis of the adverse psychotropic profile of levetiracetam, specifically focusing on the risk of irritability and aggression. The researchers conducted a candidate gene-based association study, analyzing genetic variations related to dopaminergic activity. Their findings suggest that genetic variation in dopaminergic activity may play a role in the risk for psychiatric side effects of levetiracetam.

Genetic Predisposition: Navigating the Desert of Side Effects

This research highlights the importance of considering individual genetic factors when prescribing medications. The study's findings suggest that certain genetic variations may increase the risk of psychiatric side effects from levetiracetam. This underscores the need for careful monitoring and personalized treatment approaches to minimize potential adverse events.

Navigating the Desert of Epilepsy Treatment

Epilepsy is a complex neurological condition, and this research provides valuable insights into the potential role of genetics in the development of side effects from levetiracetam. It emphasizes the importance of personalized medicine and the need for continued research to better understand the complex interplay between genetics, medications, and individual responses to treatment.

Dr.Camel's Conclusion

This research highlights the potential role of genetic variation in influencing the risk of psychiatric side effects from levetiracetam. It underscores the importance of personalized medicine and careful consideration of individual genetic factors when prescribing medications. It is a reminder that the desert of epilepsy treatment is vast and complex, requiring a multifaceted approach to ensure patient safety and well-being.

Date :
  1. Date Completed 2013-03-04
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

22881836

DOI: Digital Object Identifier

10.1111/j.1528-1167.2012.03603.x

Related Literature

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・Side Effects of levetiracetam
SNS
PICO Info
in preparation
Languages

English

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