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Bioavailability of intranasal vs. rectal diazepam.

Author: BrundageRichard, CloydJames, IvaturiVijay, KrielRobert, LoewenGordon, MansbachHank

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study compared the tolerability and pharmacokinetics of two investigational nasal formulations of diazepam (DZP) with DZP rectal gel. The study found that both intranasal formulations were well tolerated and exhibited relatively rapid, but variable, absorption.
Paper Details　
Original Abstract of the Article :
There remains an unmet medical need in the out-of-hospital management of seizure emergencies because older children and adults often refuse treatment with diazepam rectal gel due to social objections. We have previously reported that intranasal diazepam (DZP) administration is feasible, with maximum...See full text at original site
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引用元：
https://doi.org/10.1016/j.eplepsyres.2012.07.018

データ提供：米国国立医学図書館（NLM）

Intranasal Diazepam: A Promising Alternative for Seizure Management

Seizure emergencies can be frightening and unpredictable, requiring prompt and effective treatment. This research investigates the feasibility and effectiveness of intranasal diazepam as a potential alternative to rectal diazepam for seizure management. The authors compared the pharmacokinetic profiles and tolerability of intranasal and rectal diazepam formulations, exploring the potential for a more acceptable and effective treatment option.

Intranasal Diazepam: A Viable Alternative for Seizure Management

The study's findings demonstrate that intranasal diazepam can achieve comparable plasma concentrations and time to maximum concentration compared to rectal diazepam. This suggests the potential for intranasal diazepam to be a viable alternative for seizure management, especially for patients who may find rectal administration less acceptable.

Optimizing Intranasal Diazepam for Seizure Management

While intranasal diazepam holds promise, further research is needed to optimize formulation and improve consistency of absorption. The authors recognize the need for continued development to ensure that intranasal diazepam becomes a reliable and effective treatment option for seizure emergencies.

Dr.Camel's Conclusion

This research on intranasal diazepam is like discovering a new route through a treacherous desert landscape. The authors' findings suggest that intranasal diazepam can be a promising alternative for seizure management, offering a potentially more acceptable and effective treatment option for patients. Further research is needed to optimize the formulation and improve its consistency, but the potential benefits for those experiencing seizure emergencies are significant.

Date :
  1. Date Completed 2013-10-22
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

22981338

DOI: Digital Object Identifier

10.1016/j.eplepsyres.2012.07.018

Related Literature

Article Analysis
・Effects of diazepam rectal
SNS
PICO Info
in preparation
Languages

English

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