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Protective effects of alanyl-glutamine supplementation against nelfinavir-induced epithelial impairment in IEC-6 cells and in mouse intestinal mucosa.

Author: Braga-NetoManuel B, BritoGerly A C, GuerrantRichard L, LeitaoRenata F, LimaAldo A, NoronhaFrancisco J, OliveiraBruna M C, RodriguesRaphael S, WarrenCirle A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study evaluated the effects of nelfinavir (NFV), an HIV PI, and of alanyl-glutamine (AQ) supplementation, on intestinal cell migration, proliferation, apoptosis and necrosis.
Paper Details　
Original Abstract of the Article :
Human Immunodeficiency Virus (HIV) protease inhibitors (PI) remain a crucial component of highly active therapy (HAART) and recently have been demonstrated to have potent antitumor effect on a wide variety of tumor cell lines. However, discontinuation of therapy is an important issue, which may be r...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542240/

データ提供：米国国立医学図書館（NLM）

Protecting the Intestinal Mucosa from the Effects of HIV Protease Inhibitors

HIV protease inhibitors (PIs) are essential components of antiretroviral therapy, but they can have side effects, including intestinal damage. This research investigated the protective effects of alanyl-glutamine (AQ) supplementation against nelfinavir-induced intestinal damage. Imagine a desert ecosystem, where plants and animals depend on each other for survival. Similarly, our intestinal lining plays a crucial role in maintaining our health. This research explores how to protect this delicate ecosystem from the harmful effects of HIV medications.

Alanyl-Glutamine Shows Promise for Mitigating Intestinal Damage

The study found that AQ supplementation protected intestinal cells from the damaging effects of nelfinavir. This is like finding a special type of plant that helps to restore the desert's ecosystem after a drought. AQ supplementation may be a valuable tool for minimizing the side effects of HIV protease inhibitors and improving the health of individuals living with HIV.

Preventing Intestinal Side Effects is Important for HIV Treatment

This research underscores the importance of addressing the gastrointestinal side effects of HIV medications. Just as a camel needs a healthy digestive system to survive the desert, individuals with HIV need to maintain a healthy intestinal lining. This study provides valuable insights into ways to protect the intestinal mucosa and improve the quality of life for individuals living with HIV.

Dr.Camel's Conclusion

This study is a reminder that even in the realm of complex medical treatments, the delicate balance of our natural systems plays a critical role. Just as a camel needs a healthy digestive system to thrive in the desert, individuals with HIV need to protect their intestinal lining to combat the effects of medication. This research highlights the importance of understanding the complex interactions between medication and the human body to optimize treatment outcomes.

Date :
  1. Date Completed 2013-06-26
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

22986234

DOI: Digital Object Identifier

PMC3542240

Related Literature

Article Analysis
・Side Effects of nelfinavir
SNS
PICO Info
in preparation
Languages

English

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