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A pilot randomised controlled trial in intensive care patients comparing 7 days' treatment with empirical antibiotics with 2 days' treatment for hospital-acquired infection of unknown origin.

Author: HaycoxA, HoutenR, KempI, LaneS, MatataB, PathakD, SaulD, ScawnN, StablesR

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A pilot randomized trial investigated the effectiveness of 48 hours of broad-spectrum antibiotic treatment for suspected sepsis of unknown origin in the cardiac intensive care unit (ICU). The study also explored the predictive power of newer sepsis biomarkers.
Paper Details　
Original Abstract of the Article :
Management of cardiac intensive care unit (ICU) sepsis is complicated by the high incidence of systemic inflammatory response syndrome, which mimics sepsis but without an infective cause. This pilot randomised trial investigated whether or not, in the ICU, 48 hours of broad-spectrum antibiotic treat...See full text at original site
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引用元：
https://doi.org/10.3310/hta16360

データ提供：米国国立医学図書館（NLM）

Antibiotics and Sepsis in the Intensive Care Unit: A Short-Term Approach

Sepsis, a life-threatening condition caused by an overwhelming immune response to infection, is a major concern in intensive care units (ICUs). This research investigates whether a short-term antibiotic regimen of 48 hours is sufficient for treating suspected sepsis of unknown origin in ICU patients. The pilot randomized trial suggests that a 48-hour antibiotic regimen may be adequate in some cases, but further research is needed to validate these findings.

A New Path in Sepsis Management: Short and Sweet

This research explores a potentially shorter and more targeted approach to treating sepsis in ICU patients. The study offers valuable insights into the potential of optimizing antibiotic regimens for sepsis, but further research is needed to validate these findings and ensure patient safety.

A Sandstorm of Sepsis: Seeking the Oasis of Effective Treatment

Imagine a vast desert, where every gust of wind can trigger a sandstorm, much like sepsis in the ICU. This research offers a potential oasis of hope, a shorter and more targeted approach to antibiotic treatment for sepsis.

Dr. Camel's Conclusion

This research suggests that a short-term antibiotic regimen may be sufficient for treating suspected sepsis of unknown origin in some ICU patients, but further research is warranted to confirm its effectiveness and safety.

Date :
  1. Date Completed 2013-02-27
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23010339

DOI: Digital Object Identifier

10.3310/hta16360

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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