Effects of famotidine or an antacid preparation on the pharmacokinetics of nilotinib in healthy volunteers.

Author: BédouchaVéronique, HussainiAzra, McCullochTracey, NovickSteven, YinOphelia Q P, ZhengCheng, ZhouWei

Paper Details 
Original Abstract of the Article :
PURPOSE: This study evaluated the effects of either famotidine or antacid on the pharmacokinetics of nilotinib in healthy subjects, with the specific focus to explore different dosing separation schemes leading to a minimized drug-drug interaction. METHODS: Fifty-two subjects were randomized to rec...See full text at original site
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引用元:
https://doi.org/10.1007/s00280-012-1999-3

データ提供:米国国立医学図書館(NLM)

Navigating the Pharmacokinetic Landscape of Nilotinib: Minimizing Drug-Drug Interactions

In the vast and ever-evolving desert of pharmaceutical research, we often encounter the complexities of drug-drug interactions. This research delves into the intricate interplay between nilotinib, a tyrosine kinase inhibitor used to treat chronic myeloid leukemia, and other commonly used medications. This study, like a careful guide through the sands of pharmacokinetics, investigates the impact of famotidine and antacid preparations on the pharmacokinetic profile of nilotinib.

Minimizing Drug-Drug Interactions: A Quest for Optimal Treatment

The researchers, like skilled pharmacists navigating a delicate balance of drug interactions, have meticulously evaluated the effects of famotidine and antacid preparations on nilotinib absorption. Their findings, like a clear path through a maze of potential interactions, suggest that neither famotidine nor antacid significantly affect the pharmacokinetics of nilotinib when administered according to the recommended dosing schedules. This research, like a well-placed oasis in the desert of drug interactions, offers valuable guidance for clinicians and patients seeking to optimize nilotinib treatment.

Ensuring Treatment Safety: A Priority in the Pharmaceutical Desert

This research, like a compass pointing towards patient safety, emphasizes the importance of understanding and minimizing drug-drug interactions. The findings provide valuable information for clinicians and patients, enabling them to make informed decisions regarding the safe and effective use of nilotinib. This research, like a well-stocked caravan traversing the desert, equips us with the knowledge and tools to navigate the complex landscape of drug interactions with greater confidence.

Dr.Camel's Conclusion

This research, like a camel traversing the vast desert of pharmacokinetics, offers valuable insights into the impact of famotidine and antacid preparations on nilotinib absorption. The findings provide valuable guidance for clinicians and patients, enabling them to minimize drug-drug interactions and optimize nilotinib treatment.

Date :
  1. Date Completed 2013-02-26
  2. Date Revised 2022-01-14
Further Info :

Pubmed ID

23070146

DOI: Digital Object Identifier

10.1007/s00280-012-1999-3

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Languages

English

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