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Cardiovascular safety of anagrelide in healthy subjects: effects of caffeine and food intake on pharmacokinetics and adverse reactions.

Author: DatinoTomás, Fernández-AvilésFrancisco, Figueiras-GrailletLourdes, FranklinRichard, GamaJoubert G, JonesChristopher, Martínez-SellésManuel

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Anagrelide is a medication used to reduce high platelet counts in essential thrombocythaemia (ET), a rare blood disorder. Anagrelide is broken down by the body's CYP1A2 enzyme. Previous studies on how food affects anagrelide absorption were conducted before the active metabolite, 3-hydroxyanagrelide, was identified.
Paper Details　
Original Abstract of the Article :
Essential thrombocythaemia (ET) is a rare clonal myeloproliferative disorder characterized by a sustained elevation in platelet count and megakaryocyte hyperplasia. Anagrelide is used in the treatment of ET, where it has been shown to reduce platelet count. Anagrelide is metabolized by cytochrome P4...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586167/

データ提供：米国国立医学図書館（NLM）

Anagrelide: Navigating the Sands of Thrombocythaemia Treatment

Essential thrombocythaemia (ET), a rare clonal myeloproliferative disorder, presents a unique challenge for hematologists. This study investigates the cardiovascular safety of anagrelide, a drug used to treat ET, exploring the effects of caffeine and food intake on its pharmacokinetics and potential adverse reactions.

Anagrelide's Safety Profile: A Complex Landscape

The study provides valuable insights into the pharmacokinetics of anagrelide, highlighting the potential interactions with caffeine and food. Understanding these interactions is crucial for optimizing treatment strategies and minimizing potential adverse effects. Like navigating a shifting sand dune, clinicians must carefully consider these factors when prescribing anagrelide to patients with ET.

Navigating the Desert of Thrombocythaemia

This research emphasizes the importance of individualized care in managing ET. Like a camel adapting to the harsh desert environment, clinicians must tailor treatment strategies to the specific needs of each patient, taking into account their individual risk factors and potential interactions with other medications or substances.

Dr. Camel's Conclusion

The study offers valuable insights into the cardiovascular safety of anagrelide, a crucial aspect of managing ET. Understanding the influence of caffeine and food intake on anagrelide's pharmacokinetics helps clinicians make informed decisions to optimize treatment and minimize potential risks. Like a wise traveler navigating a desert, clinicians must be vigilant in monitoring their patients and adjusting treatment strategies as needed.

Date :
  1. Date Completed 2013-07-02
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23184666

DOI: Digital Object Identifier

PMC3586167

Related Literature

Article Analysis
・Effects of anagrelide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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