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The Zelnorm epidemiologic study (ZEST): a cohort study evaluating incidence of abdominal and pelvic surgery related to tegaserod treatment.
Author: EarnestDavid L, KuoBraden, LemboAnthony, QuinnSherry, RiveroElena, SeegerJohn D, WalkerAlexander M
Original Abstract of the Article :
BACKGROUND: Pre-marketing clinical studies of tegaserod suggested an increased risk of abdominal surgery, particularly cholecystectomy. We sought to quantify the association between tegaserod use and the occurrence of abdominal or pelvic surgery, including cholecystectomy. METHODS: This cohort stud...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536557/
データ提供:米国国立医学図書館(NLM)
Tegaserod and Abdominal/Pelvic Surgery: A Cohort Study Evaluation
The world of [pharmacovigilance] involves closely monitoring the safety and effectiveness of drugs. This research delves into the potential association between [tegaserod], a medication used to treat [irritable bowel syndrome], and the incidence of [abdominal or pelvic surgery]. Imagine this as a careful examination of a desert caravan, looking for any potential link between the medication and the need for surgical interventions.
The study used a [cohort study design] to compare the incidence of [abdominal or pelvic surgery] among [tegaserod users] and a control group. This research is like tracking the journeys of two caravans through the desert, comparing their experiences to identify any potential associations between medication use and surgical needs.
No Increased Risk
The study found no evidence to suggest that [tegaserod use] increased the risk of [abdominal or pelvic surgery], including [cholecystectomy]. This research is like finding no significant differences in the journey experiences of the two caravans, suggesting that the medication is not linked to increased surgical needs.
Patient Safety
This research reassures the safety of [tegaserod] in terms of its association with [abdominal or pelvic surgery]. It provides valuable insights for [clinicians and patients] when considering the use of this medication for [irritable bowel syndrome].
Dr. Camel's Conclusion
This research is like a clear desert sky, dispelling any concerns about a potential link between tegaserod and abdominal/pelvic surgery. It reassures us about the safety of this medication for treating irritable bowel syndrome. It's a reminder that even in the vast desert of medicine, we can sometimes find clear pathways and reliable guides to help us make informed decisions.
Date :
- Date Completed 2013-06-14
- Date Revised 2021-10-21
Further Info :
Related Literature
English
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