Preventive effects of fluvastatin in rat mammary carcinogenesis.

Author: AdamicováKatarína, BojkováBianka, DobrotaDušan, KajoKarol, KapinováAndrea, KassayováMonika, KubatkaPeter, OrendášPeter, PéčMartin, StollárováNadežda, ŠkardaJozef, ŽihlavníkováKatarína

Paper Details 
Original Abstract of the Article :
On the basis of preclinical and clinical evidence, statins lead to risk reduction of several types of neoplasia including breast cancer. This study is the first report on the preventive effects of fluvastatin in experimental breast cancer in vivo. In this experiment, the antineoplastic effects of fl...See full text at original site
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引用元:
https://doi.org/10.1097/CEJ.0b013e32835b385d

データ提供:米国国立医学図書館(NLM)

Fluvastatin: A Potential Weapon Against Breast Cancer

The field of cancer research is constantly seeking new ways to prevent and treat various forms of cancer. This study investigates the preventive effects of fluvastatin, a statin, on breast cancer in female rats. The experiment involved administering fluvastatin at two concentrations to rats with chemically induced mammary tumors. The researchers observed that fluvastatin, particularly at higher concentrations, significantly suppressed tumor frequency and incidence compared to the control group. Further analysis revealed a decrease in vascular endothelial growth factor receptor-2 expression and an increase in caspase-3 in tumor cells after fluvastatin treatment, suggesting its potential to inhibit tumor growth and promote apoptosis.

Statins: A New Frontier in Cancer Prevention?

The results of this study suggest that fluvastatin, and possibly other statins, could play a significant role in cancer prevention. While further research is needed to confirm these findings in humans, the potential benefits of statins in reducing cancer risk are promising. However, it's important to note that fluvastatin also had some side effects, including decreased femur bone thickness and body weight, highlighting the need for careful monitoring and further research.

A Healthy Lifestyle: The Foundation of Cancer Prevention

While fluvastatin shows potential in cancer prevention, remember that a healthy lifestyle remains paramount. This includes a balanced diet, regular exercise, and avoidance of smoking and excessive alcohol consumption. These factors contribute to overall health and can reduce the risk of various diseases, including cancer. By adopting these habits, we can create a robust foundation for good health and well-being.

Dr.Camel's Conclusion

Just as a camel adapts to the harsh desert environment, we must adapt our lifestyles to promote optimal health. This study suggests that fluvastatin might have a place in cancer prevention, but it's important to remember that a healthy lifestyle is the foundation of a strong and resilient body. Further research is needed to fully understand the potential benefits and risks of fluvastatin, but the findings offer a glimpse into the vast and promising landscape of cancer prevention.

Date :
  1. Date Completed 2013-11-07
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

23212095

DOI: Digital Object Identifier

10.1097/CEJ.0b013e32835b385d

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PICO Info
in preparation
Languages

English

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