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Clomiphene citrate versus high doses of gonadotropins for in vitro fertilisation in women with compromised ovarian reserve: a randomised controlled non-inferiority trial.

Author: AlagnaFederica, ArfusoVeronica, BriganteClaudio, CandianiMassimo, FadiniRubens, Levi-SettiPaolo E, Mignini-RenziniMario, PaffoniAlessio, RagniGuido, ScarduelliClaudia, SomiglianaEdgardo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This randomized controlled trial compared clomiphene citrate to gonadotropins for ovarian stimulation in women with compromised ovarian reserve undergoing IVF. Although the gonadotropin group had more oocytes retrieved and higher embryo transfer rates, delivery rates were similar between the groups. However, the cost per delivery was significantly lower with clomiphene citrate.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The aim of the present randomised controlled non-inferiority trial is to test whether in women with compromised ovarian reserve requiring in vitro fertilisation, a protocol of ovarian stimulation using exclusively clomiphene citrate performs similarly to a regimen with high doses of gona...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551801/

データ提供：米国国立医学図書館（NLM）

Clomiphene Citrate vs. Gonadotropins: A Cost-Effective Approach for IVF in Women with Compromised Ovarian Reserve

In the field of assisted reproductive technology, the treatment of women with compromised ovarian reserve presents unique challenges. This study investigated the effectiveness of clomiphene citrate compared to high doses of gonadotropins for in vitro fertilization (IVF). The researchers aimed to determine if a protocol using exclusively clomiphene citrate could achieve similar success rates to a regimen with high-dose gonadotropins. The study was interrupted before reaching the target sample size but showed that while high-dose gonadotropins resulted in more oocytes retrieved and a higher likelihood of embryo transfer, the delivery rates were similar between the two groups. Interestingly, clomiphene citrate was considerably less expensive.

Clomiphene Citrate - A Promising Alternative for IVF

This study suggests that clomiphene citrate can be a viable and more affordable alternative for ovarian stimulation in women with compromised ovarian reserve undergoing IVF. The similar delivery rates achieved with clomiphene citrate compared to high-dose gonadotropins represent a significant finding.

Cost-Effectiveness in Reproductive Healthcare

This research highlights the importance of considering cost-effectiveness in reproductive healthcare. The study's findings could have a significant impact on patient care and potentially reduce the financial burden associated with IVF. It's like navigating a desert, finding a path that leads to the desired destination without depleting your resources.

Dr.Camel's Conclusion

This study provides compelling evidence that clomiphene citrate can be a cost-effective treatment option for women with compromised ovarian reserve undergoing IVF. The results suggest that clomiphene citrate can achieve comparable success rates to high-dose gonadotropins while significantly reducing treatment costs. This is a valuable finding that could potentially improve access to IVF for more women.

Date :
  1. Date Completed 2013-10-17
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23249758

DOI: Digital Object Identifier

PMC3551801

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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