Paper Details

  1. Home
  2. Paper Details

Dissociation of the pharmacological effects of THC by mTOR blockade.

Author: Busquets-GarciaArnau, Gomis-GonzálezMaria, MaldonadoRafael, MarsicanoGiovanni, OzaitaAndrés, PuighermanalEmma

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the role of the mTOR pathway in the pharmacological effects of delta9-tetrahydrocannabinol (THC). Inhibition of the mTOR pathway prevented the anxiogenic- and amnesic-like effects of THC but did not affect its anxiolytic, hypothermic, hypolocomotor, and antinociceptive effects. These findings suggest potential for targeting the endocannabinoid system to segregate beneficial and negative effects of cannabinoid agonists.
Paper Details　
Original Abstract of the Article :
The potential therapeutic benefits of cannabinoid compounds have raised interest in understanding the molecular mechanisms that underlie cannabinoid-mediated effects. We previously showed that the acute amnesic-like effects of delta9-tetrahydrocannabinol (THC) were prevented by the subchronic inhibi...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656376/

データ提供：米国国立医学図書館（NLM）

Deconstructing THC: Exploring the Role of mTOR in Cannabinoid Effects

The endocannabinoid system, a complex network of neurotransmitters and receptors, plays a crucial role in regulating various physiological processes. This study delves into the molecular mechanisms underlying the effects of delta9-tetrahydrocannabinol (THC), the psychoactive component of cannabis. The researchers investigated the role of the mammalian target of rapamycin (mTOR) pathway, a signaling pathway involved in cell growth and metabolism, in mediating THC's effects.

mTOR: A Key Player in THC's Effects

This research revealed that the mTOR pathway plays a significant role in mediating some of THC's effects, including its amnesic-like and anxiogenic effects. Inhibition of the mTOR pathway was found to prevent these negative effects, suggesting that targeting this pathway may be a potential strategy for mitigating THC's unwanted side effects. These findings offer valuable insights into the complex interplay between the endocannabinoid system and cellular signaling pathways.

Navigating the Desert of Cannabinoid Research: A Need for Precision

This research highlights the importance of understanding the molecular mechanisms underlying THC's effects, particularly when considering its potential therapeutic applications. As we journey through the desert of cannabinoid research, it's crucial to carefully dissect the complex interplay between different signaling pathways and receptors to maximize therapeutic potential while minimizing unwanted side effects.

Dr.Camel's Conclusion

This research reveals that the mTOR pathway plays a significant role in mediating some of THC's effects, particularly its amnesic-like and anxiogenic effects. This finding suggests that targeting the mTOR pathway could be a potential strategy for mitigating THC's unwanted side effects. As we continue to explore the complex desert of cannabinoid research, it's essential to understand the intricate interplay between different signaling pathways to optimize therapeutic outcomes.
Date :
  1. Date Completed 2014-01-24
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

23358238

DOI: Digital Object Identifier

PMC3656376

Related Literature

Article Analysis
・Side Effects of temsirolimus
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.