Paper Details 
Original Abstract of the Article :
Dalfampridine (Ampyra) is indicated to improve walking in patients with multiple sclerosis (MS) and was found to be effective in 35%-43% of individuals with MS in clinical trials. Dalfampridine may increase seizure risk, particularly in patients with renal impairment. A U.S. managed care expert cons...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10437843/

データ提供:米国国立医学図書館(NLM)

Improving Walking in Multiple Sclerosis: The Role of Dalfampridine

Multiple sclerosis (MS) is a complex neurological disorder that can significantly impact mobility. This study explores the use of dalfampridine (Ampyra) to improve walking in individuals with MS. The research highlights the effectiveness of dalfampridine in clinical trials, with approximately 35%-43% of individuals experiencing improvement in walking ability. However, the authors also emphasize the potential risks, particularly an increased risk of seizures, especially in patients with renal impairment.

Prior Authorization: A Key to Safe and Effective Use

To ensure safe and appropriate use of dalfampridine, a health plan implemented a two-phase prior authorization (PA) program. This program serves as a safety net, ensuring that patients who are eligible for this medication receive it while minimizing potential risks. The study highlights the importance of such programs in managing access to potentially beneficial, but also potentially risky, medications.

Balancing Benefits and Risks

The use of dalfampridine presents a classic case of balancing potential benefits with potential risks. While the drug holds promise for improving walking ability in patients with MS, it also comes with potential complications, such as an increased risk of seizures. This study emphasizes the importance of carefully weighing these factors and ensuring that patients are appropriately monitored to ensure their safety.

Dr. Camel's Conclusion

Think of the desert sands, a seemingly endless expanse, yet filled with hidden treasures and unexpected dangers. Just as a traveler must carefully navigate the desert, so too must patients with MS navigate the complexities of their condition and the potential benefits and risks of medications like dalfampridine. The use of prior authorization programs, like oases in the desert, provides a valuable tool for ensuring safety and maximizing the potential benefits of this medication.

Date :
  1. Date Completed 2013-07-22
  2. Date Revised 2023-08-23
Further Info :

Pubmed ID

23383704

DOI: Digital Object Identifier

PMC10437843

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.