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Clinical, dermoscopic and immunohistochemical assessment of actinic keratoses and evaluation of the effectiveness of diclofenac therapy with immunohistochemical analysis.

Author: DemirizMurat, KöseOsman, ÇayirliMutlu

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Actinic keratoses (AKs) are precancerous skin growths often found on sun-exposed areas. This study examined the clinical, dermatoscopic, and immunohistochemical changes in AKs treated with topical diclofenac, a medication used for skin conditions. The study found that diclofenac was effective in treating AKs, especially more severe lesions. It also observed a decrease in proliferation markers after treatment, suggesting an anti-proliferative effect of diclofenac. However, the study highlights the need for longer treatment periods to fully cure AKs.
Paper Details　
Original Abstract of the Article :
Actinic keratoses (AKs) is a keratinocytic neoplasm that typically develops on the face of elderly patients. Little is known regarding the clinical, dermatoscopic and immunohistochemical assessments of AK using topical diclofenac therapy. We sought to determine these assessments and evaluate the eff...See full text at original site
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引用元：
https://doi.org/10.1007/s00403-013-1322-0

データ提供：米国国立医学図書館（NLM）

Diclofenac: A Potential Oasis in the Desert of Actinic Keratosis

The field of dermatology is continuously seeking effective solutions for various skin conditions. This study investigates the effectiveness of topical diclofenac gel in treating actinic keratoses (AKs), a common skin condition often affecting elderly individuals. The researchers, like explorers venturing through the vast desert of skin conditions, analyzed the clinical, dermatoscopic, and immunohistochemical changes observed in patients receiving diclofenac treatment. This study provides valuable insights into the potential of diclofenac as a therapeutic agent for AK, offering hope for patients seeking relief from this persistent skin condition.

Diclofenac's Effectiveness in Treating Actinic Keratoses

The study revealed that topical diclofenac gel was effective in treating AKs, particularly Grade 3 lesions. The findings suggest that diclofenac could be a valuable tool in managing this skin condition, potentially leading to improved cosmetic outcomes and reducing the risk of skin cancer.

Implications for Skin Health and Future Research

The study's results underscore the importance of exploring topical treatments for AKs, providing a potentially less invasive and more convenient approach to management. Future research should explore the optimal duration of diclofenac treatment and investigate its potential to fully cure AKs, potentially leading to a more permanent solution for patients.

Dr.Camel's Conclusion

This research offers a glimmer of hope for patients seeking treatment for actinic keratosis. The study's findings suggest that diclofenac could be a valuable tool in managing this condition, potentially leading to improved cosmetic outcomes and reducing the risk of skin cancer. The exploration of this new therapy exemplifies the ongoing efforts to conquer the vast desert of skin conditions, bringing hope to those affected by these ailments.

Date :
  1. Date Completed 2013-10-21
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

23397597

DOI: Digital Object Identifier

10.1007/s00403-013-1322-0

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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