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Intramuscular administration of sodium benzylpenicillin in horses as an alternative to procaine benzylpenicillin.

Author: BengtssonBjörn, BerghAnna, BondessonUlf, BremerHanna, BroströmHans, BröjerJohan, Ingvast-LarssonCarina, NostellKatarina, OlofssonKarin, OlsénLena

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Sodium benzylpenicillin (Na-pc) achieved adequate antimicrobial therapy in horses, with a half-life of 1.9 hours and peak concentration of 14,600 ng/mL. However, due to increased pain and swelling compared to procaine benzylpenicillin, Na-pc is not recommended from a welfare standpoint.
Paper Details　
Original Abstract of the Article :
The aim was to supply information about the possibility of replacing the procaine salt with the sodium salt for benzylpenicillin IM treatment in horse in order to diminish the risk for procaine adverse effects. In a crossover study eight horses were given 15 mg/kg sodium benzylpenicillin (Na-pc) twi...See full text at original site
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引用元：
https://doi.org/10.1016/j.rvsc.2013.01.019

データ提供：米国国立医学図書館（NLM）

Intramuscular Administration of Sodium Benzylpenicillin in Horses as an Alternative to Procaine Benzylpenicillin

The field of [veterinary medicine] is always looking for new ways to treat [animals]. This study investigates the use of [sodium benzylpenicillin] as an alternative to [procaine benzylpenicillin] in treating [horses]. The authors conducted a [crossover study] comparing the [pharmacokinetics] and [efficacy] of [sodium benzylpenicillin] to [procaine benzylpenicillin], while also examining [pain and swelling] associated with each treatment. This research provides valuable insights into the [potential benefits and limitations] of using [sodium benzylpenicillin] in [horses].

Sodium Benzylpenicillin: A Potential Alternative for Horses?

The study suggests that [sodium benzylpenicillin] may be an effective alternative to [procaine benzylpenicillin] in terms of [antimicrobial activity]. However, it also highlights a potential drawback: [sodium benzylpenicillin] caused more [pain and swelling] than [procaine benzylpenicillin]. The authors caution that [sodium benzylpenicillin] may not be the ideal choice from a [welfare] perspective.

Choosing the Right Treatment: Balancing Efficacy and Welfare

This research reminds us of the importance of considering both [efficacy] and [welfare] when selecting treatments for [animals]. Just like a camel needs to balance its need for water and its ability to navigate the desert, we must strike a balance between [treatment effectiveness] and [animal comfort].

Dr.Camel's Conclusion

This study highlights the importance of finding the right balance between [treatment effectiveness] and [animal welfare] in [veterinary medicine]. Just like a desert traveler needs to carefully choose their path to avoid potential dangers, veterinarians must carefully consider all factors when selecting the best treatment for their patients.

Date :
  1. Date Completed 2014-02-20
  2. Date Revised 2013-05-20
Further Info :

Pubmed ID

23419937

DOI: Digital Object Identifier

10.1016/j.rvsc.2013.01.019

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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