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The pharmacokinetics and pharmacodynamics of zaleplon delivered as a thermally generated aerosol in a single breath to volunteers.

Author: AvramMichael J, CassellaJames V, KehneJohn H, SpykerDaniel A

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Inhaled zaleplon was found to be safe and well-tolerated in healthy volunteers, rapidly achieving effective plasma concentrations within 3 minutes with a mean elimination half-life of 1.24 hours. The most common adverse events included dizziness, somnolence, euphoria, headache, and visual disturbance.
Paper Details　
Original Abstract of the Article :
Pharmacokinetics, pharmacodynamics, safety, and tolerability of inhaled zaleplon were assessed in healthy volunteers. Forty participants received 0.5, 1, 2, or 4 mg zaleplon or placebo as a thermally generated aerosol in a randomized, double-blind, parallel-group, dose escalation study. Blood was co...See full text at original site
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引用元：
https://doi.org/10.1177/0091270012436886

データ提供：米国国立医学図書館（NLM）

Zaleplon: A New Approach to Rapid Sedation

The field of pharmacology seeks to develop safe and effective medications for a wide range of medical needs. This study investigates the pharmacokinetics and pharmacodynamics of zaleplon, a sedative-hypnotic drug, when delivered as a thermally generated aerosol in a single breath. The researchers explored the potential for inhaled zaleplon as a rapid and effective method for achieving sedation, offering new possibilities for managing sedation and anesthesia.

A Breath of Relief: Rapid Sedation with Inhaled Zaleplon

This study demonstrates the feasibility and safety of inhaled zaleplon as a rapid and effective means of achieving sedation. The findings suggest that this novel delivery method offers a promising alternative for managing sedation in various clinical settings, potentially revolutionizing the way we approach sedation and anesthesia.

Navigating the Desert of Sedation: Finding New Solutions

This research highlights the potential for innovative drug delivery methods to improve patient outcomes. It emphasizes the importance of exploring new avenues for managing sedation, offering a potential solution for a common challenge in healthcare. Just as a camel navigates the vast desert landscape, we must be open to new approaches and explore innovative solutions to meet the evolving needs of our patients.

Dr.Camel's Conclusion

This research offers a promising new approach to rapid sedation using inhaled zaleplon. The findings suggest that this novel delivery method can achieve effective plasma concentrations quickly and safely, potentially transforming the way we manage sedation in various clinical settings.

Date :
  1. Date Completed 2013-07-30
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

23436259

DOI: Digital Object Identifier

10.1177/0091270012436886

Related Literature

Article Analysis
・Effects of zaleplon
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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