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Risedronate-loaded Eudragit S100 microparticles formulated into tablets.

Author: CruzLetícia, FerreiraLuana M, MattiazziJuliane, PohlmannLauren, RolimClarice M B, SilvaCristiane B, VelasquezAline A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study developed risedronate-loaded Eudragit® S100 microparticles to improve patient compliance with the anti-osteoporotic drug risedronate. These microparticles, prepared by spray-drying, exhibited high encapsulation efficiency (over 90%) and controlled drug release, making them a promising dosage form for oral risedronate administration.
Paper Details　
Original Abstract of the Article :
Risedronate, an anti-osteoporotic drug, is associated with low patient compliance due to the upper gastrointestinal side-effects and stringent dosing regimes. This study aimed to prepare and characterize risedronate-loaded Eudragit® S100 microparticles and develop a final dosage form by the compress...See full text at original site
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引用元：
https://doi.org/10.3109/10837450.2013.775155

データ提供：米国国立医学図書館（NLM）

Risedronate: A New Oasis in the Desert of Osteoporosis Treatment?

The field of [pharmaceutics] is constantly striving to develop innovative drug delivery systems to improve patient compliance and outcomes. This study focuses on [risedronate], a medication used to treat [osteoporosis], and explores the potential of a novel [microparticle formulation] to enhance its delivery and minimize side effects. The researchers developed [risedronate-loaded Eudragit® S100 microparticles] and formulated them into tablets, aiming to improve the [bioavailability] of [risedronate] and reduce its [gastrointestinal side effects].

Risedronate Microparticles: A Potential Breakthrough in Osteoporosis Treatment

The study demonstrated that the developed [risedronate-loaded microparticles] exhibited controlled release characteristics, with a sustained release profile in [intestinal medium]. This suggests that the microparticle formulation could potentially improve the [bioavailability] of [risedronate] and reduce its [gastrointestinal side effects], leading to better patient compliance and outcomes. The study also highlighted the advantages of using [direct tableting] to create the final dosage form, simplifying the manufacturing process.

Risedronate Microparticles: A Step Towards Improved Osteoporosis Management

This research offers a promising approach to improving the treatment of [osteoporosis]. The development of [risedronate-loaded microparticles] could potentially enhance the [bioavailability] of this medication and reduce its [gastrointestinal side effects], leading to better patient outcomes and improved quality of life. As a researcher, I am always fascinated by the ingenuity of scientists and pharmacists who continually strive to find new and better ways to deliver medications to patients. The desert of [pharmaceutics] is vast, and the quest for innovative drug delivery systems is an ongoing journey.

Dr.Camel's Conclusion

The study highlights the potential of risedronate-loaded Eudragit® S100 microparticles as a promising dosage form for oral risedronate administration, potentially improving bioavailability and reducing gastrointestinal side effects.

Date :
  1. Date Completed 2014-07-14
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

23506303

DOI: Digital Object Identifier

10.3109/10837450.2013.775155

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Languages

English

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