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Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity.

Author: BersDonald M, DieckeSebastian, GongTingyu, KnowlesJoshua W, LanFeng, LeeAndrew S, LiangPing, NguyenPatricia K, RobbinsRobert C, SallamKarim, Sanchez-FreireVeronica, WangPaul J, WangYongming, WuJoseph C

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A library of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) from patients with various hereditary cardiac disorders was generated to model differences in cardiac drug toxicity susceptibility for patients of different genetic backgrounds.
Paper Details　
Original Abstract of the Article :
Cardiotoxicity is a leading cause for drug attrition during pharmaceutical development and has resulted in numerous preventable patient deaths. Incidents of adverse cardiac drug reactions are more common in patients with preexisting heart disease than the general population. Here we generated a libr...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/23519760

データ提供：米国国立医学図書館（NLM）

A Diverse Desert of Cardiotoxicity: Exploring Personalized Medicine Through hiPSC-CMs

The field of drug development is a vast and complex desert, with researchers constantly navigating the challenges of drug toxicity. This study, like a camel caravan traversing a diverse landscape, explores the potential of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to personalize drug screening and predict cardiotoxicity. The researchers created a library of hiPSC-CMs from individuals with various hereditary cardiac disorders, providing a unique opportunity to understand how genetic variations influence drug responses.

The Desert of Cardiotoxicity: A Diverse Landscape of Drug Responses

The study demonstrates the power of hiPSC-CMs in modeling patient-specific responses to drugs. By utilizing hiPSC-CMs from individuals with different genetic backgrounds, researchers can explore the diverse landscape of cardiotoxicity, offering a more personalized approach to drug development. Imagine a desert landscape with various oases, each with its own unique characteristics. This study reveals the potential to customize our approach to drug development, ensuring the safety and efficacy of medications for each individual.

Navigating the Desert: Toward Personalized Drug Development

This research provides a roadmap for personalized drug development. By leveraging hiPSC-CMs, we can create a more accurate picture of drug responses, reducing the risk of cardiotoxicity and ultimately improving patient safety. Imagine a future where drug development is tailored to individual needs, leading to a healthier and safer landscape for all. This study is a significant step forward in this quest for personalized medicine.

Dr.Camel's Conclusion

This study, like a compass guiding us through the desert of drug development, highlights the potential of hiPSC-CMs to personalize drug screening and predict cardiotoxicity. By understanding the unique genetic landscape of each individual, we can create a safer and more effective approach to drug development. This research represents a significant step forward in our journey toward a personalized and safer future for all.

Date :
  1. Date Completed 2013-06-25
  2. Date Revised 2023-02-07
Further Info :

Pubmed ID

23519760

DOI: Digital Object Identifier

NIHMS468874

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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