Daclizumab high-yield process in relapsing-remitting multiple sclerosis (SELECT): a randomised, double-blind, placebo-controlled trial.

Author: , ElkinsJacob, GiovannoniGavin, GoldRalf, HavrdovaEva, MontalbanXavier, O'NeillGilmore, RadueErnst-Wilhelm, RanaJitesh, RiesterKatherine, RobinsonRandy, SelmajKrzysztof, StefoskiDusan

Paper Details 
Original Abstract of the Article :
Daclizumab, a humanised monoclonal antibody, modulates interleukin-2 signalling by blocking the α subunit (CD25) of the interleukin-2 receptor. We assessed whether daclizumab high-yield process (HYP) would be effective when given as monotherapy for a 1 year treatment period in patients with relapsin...See full text at original site
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引用元:
https://doi.org/10.1016/S0140-6736(12)62190-4

データ提供:米国国立医学図書館(NLM)

Daclizumab: A New Weapon in the Fight Against Multiple Sclerosis

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. This study explores the effectiveness of daclizumab, a humanized monoclonal antibody, as a potential treatment for relapsing-remitting MS.

The researchers found that daclizumab high-yield process (HYP) significantly reduced the frequency of relapses in patients with relapsing-remitting MS over a one-year treatment period. This discovery offers hope for patients seeking relief from the debilitating symptoms of MS. It's like finding a powerful new weapon in the fight against a persistent desert sandstorm.

The Importance of Targeting the Immune System

This study highlights the importance of targeting the immune system in the management of MS. Daclizumab works by modulating interleukin-2 signaling, effectively calming the immune storm that contributes to the development of MS. It's like creating a temporary oasis of calm in the midst of a raging sandstorm, allowing the body to heal and recover.

Understanding the Limitations and Opportunities

While this study provides encouraging results, it is important to note that it was a randomized, double-blind, placebo-controlled trial with a relatively small sample size. Further research is needed to confirm these findings and explore the long-term safety and efficacy of daclizumab in patients with MS. It's like carefully mapping the desert, ensuring that we understand the full scope of this new weapon's potential and its potential side effects before deploying it widely.

Dr.Camel's Conclusion

This study provides promising evidence for the effectiveness of daclizumab in reducing relapses in patients with relapsing-remitting MS. Further research is needed to confirm these findings and explore the long-term benefits and risks of this treatment. It's a reminder that the quest for effective MS treatments is ongoing, and new discoveries continue to emerge in the vast desert of medical research.

Date :
  1. Date Completed 2013-07-15
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

23562009

DOI: Digital Object Identifier

10.1016/S0140-6736(12)62190-4

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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