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The adverse event profile of perampanel: meta-analysis of randomized controlled trials.

Author: CincottaM, GiovannelliF, GrilloE, VerrottiA, ZaccaraG

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Perampanel was significantly associated with an increased risk of adverse event-related study withdrawals at 4 mg/day and 12 mg/day. Vestibulocerebellar adverse events (dizziness, ataxia), sedative effects (somnolence), irritability and weight increase were significantly associated with perampanel treatment.
Paper Details　
Original Abstract of the Article :
BACKGROUND AND PURPOSE: To identify adverse events (AEs) significantly associated with perampanel treatment in double-blind clinical studies (RCTs). Serious AEs, study withdrawals due to AEs and dose-effect responses of individual AEs were also investigated. METHODS: All placebo controlled, double-...See full text at original site
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引用元：
https://doi.org/10.1111/ene.12170

データ提供：米国国立医学図書館（NLM）

Perampanel: A Review of Adverse Events in Clinical Trials

Perampanel, an anti-epileptic drug, has shown promise in treating various neurological conditions. This meta-analysis delves into the adverse event profile of perampanel, analyzing data from nine double-blind, placebo-controlled clinical trials involving nearly 4000 patients. The authors systematically assessed the association between perampanel and various adverse events, finding that dizziness, ataxia, somnolence, irritability, and weight increase were significantly associated with treatment. The meta-analysis provides a comprehensive overview of the potential risks associated with perampanel, underscoring the importance of careful monitoring and managing these adverse events.

Weighing the Risks and Benefits of Perampanel

The meta-analysis highlights the need for a balanced approach when prescribing perampanel. While it offers potential therapeutic benefits, healthcare providers must carefully consider the risks associated with its use, particularly the potential for dizziness, ataxia, somnolence, irritability, and weight increase. Just as a skilled navigator must assess the risks and benefits of different paths, healthcare providers must weigh the potential benefits of perampanel against the potential for adverse events.

Navigating the Complexities of Anti-Epileptic Treatment

This meta-analysis underscores the importance of individualized patient care when prescribing anti-epileptic drugs. Healthcare providers must carefully monitor patients for potential adverse events, adjusting treatment strategies as needed to minimize risks and maximize therapeutic benefits. By navigating the complex terrain of anti-epileptic treatment with knowledge, vigilance, and compassion, we can provide optimal care for individuals living with epilepsy.

Dr. Camel's Conclusion

This meta-analysis provides a comprehensive review of the adverse event profile of perampanel, highlighting the importance of careful monitoring and management of potential risks associated with its use. By navigating the complex landscape of anti-epileptic treatment with knowledge and vigilance, healthcare providers can ensure patient safety and optimize therapeutic outcomes.
Date :
  1. Date Completed 2014-02-07
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

23607817

DOI: Digital Object Identifier

10.1111/ene.12170

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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