Effects of short-term estradiol and norethindrone acetate treatment on the breasts of normal postmenopausal women.

Author: ButlerRyan, ChengGuojun, GustafssonJan-Åke, LandgrenBritt-Marie, WarnerMargaret, WilczekBrigitte

Paper Details 
Original Abstract of the Article :
OBJECTIVE: The aim of this study was to evaluate among postmenopausal women the effects of a 3-month treatment with estradiol (E2) alone or in combination with norethindrone acetate (NA) on expression of hormone receptors and proliferation in the breast as well as on lipids and climacteric symptoms....See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/23615640

データ提供:米国国立医学図書館(NLM)

Estrogen and Progesterone: A Journey Through the Postmenopausal Breasts

This study investigates the effects of short-term estrogen and progesterone treatment on the breasts of postmenopausal women. The researchers followed 60 postmenopausal women who received either estradiol alone or a combination of estradiol and norethindrone acetate for 12 weeks. They found that both treatments resulted in an increase in progesterone receptor expression but did not significantly affect estrogen receptors, androgen receptors, proliferation, or breast density. The study also found that both treatments were effective in relieving hot flashes and sweating, highlighting the potential benefits of hormone therapy in managing menopausal symptoms. This research provides insights into the potential benefits and risks of hormone therapy in postmenopausal women, guiding treatment decisions and ensuring optimal patient care.

Hormone Therapy: A Balancing Act for Postmenopausal Health

This research suggests that short-term estrogen and progesterone therapy can be effective in managing menopausal symptoms, particularly hot flashes and sweating, without significantly affecting breast density or proliferation. The findings also suggest that the combination of estradiol and norethindrone acetate may be more effective in reducing cholesterol levels compared to estradiol alone. This information is valuable for healthcare professionals in guiding treatment decisions for postmenopausal women, balancing the potential benefits and risks of hormone therapy.

Navigating the Desert of Menopause: Finding a Balance

This research provides valuable insights into the effects of hormone therapy on postmenopausal women. The findings highlight the importance of considering individual patient needs and weighing the potential benefits and risks of hormone therapy. It's like navigating a desert, where finding the right balance between the elements is essential for survival and well-being. This research helps guide us towards finding that balance in managing menopausal symptoms and ensuring optimal health in postmenopausal women.

Dr.Camel's Conclusion

This research is a reminder that hormone therapy can be a useful tool in managing menopausal symptoms, but it's important to consider the potential risks and benefits for each individual woman. This study highlights the importance of a personalized approach to hormone therapy, tailored to the specific needs and preferences of each patient.

Date :
  1. Date Completed 2014-01-06
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

23615640

DOI: Digital Object Identifier

00042192-201305000-00005

Related Literature

SNS
PICO Info
in preparation
Languages

English

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