Effects of ketoconazole and esomeprazole on the pharmacokinetics of pazopanib in patients with solid tumors.

Author: BotbylJeffrey, EdenfieldJeffery W, GibbonDarlene G, GregoryCharles, LindquistDiana, MartinJulie C, SteinMark N, StephensonJoseph J, SuttleA Benjamin, TadaHiroomi, TanAntoinette R

Paper Details 
Original Abstract of the Article :
The metabolism of pazopanib is primarily mediated by CYP3A4. The solubility of pazopanib is pH-dependent, and an elevated gastric pH may decrease its bioavailability. This study evaluated the effect of a potent CYP3A4 inhibitor, ketoconazole, and the proton pump inhibitor esomeprazole on the pharmac...See full text at original site
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引用元:
https://doi.org/10.1007/s00280-013-2164-3

データ提供:米国国立医学図書館(NLM)

Investigating the Pharmacokinetic Interactions of Pazopanib with Ketoconazole and Esomeprazole

This study examines the pharmacokinetic interactions of pazopanib, a tyrosine kinase inhibitor used to treat solid tumors, with ketoconazole, a potent CYP3A4 inhibitor, and esomeprazole, a proton pump inhibitor. The authors aimed to understand the potential impact of these co-administered medications on the pharmacokinetics and safety of pazopanib. The study's findings provide valuable insights into the potential for drug interactions and the need for careful monitoring of pazopanib therapy when co-administered with other medications. This research highlights the importance of considering drug interactions and the need for individualized treatment approaches in cancer therapy.

Navigating the Complex World of Drug Interactions

This study underscores the importance of understanding drug interactions, particularly in the context of cancer therapy. The research examined the potential impact of ketoconazole and esomeprazole on the pharmacokinetics of pazopanib, highlighting the need for careful monitoring of pazopanib therapy when co-administered with other medications. This research emphasizes the importance of considering drug interactions and the need for individualized treatment approaches in cancer care.

Ensuring Patient Safety in Cancer Therapy

This study highlights the importance of patient safety in cancer therapy. The research examined the potential for drug interactions between pazopanib and other medications, emphasizing the need for careful monitoring and individualized treatment approaches. This research reinforces the importance of understanding drug interactions and the need for ongoing vigilance in ensuring patient safety.

Dr. Camel's Conclusion

The journey through cancer treatment is often marked by a series of twists and turns, and navigating the complex landscape of drug interactions is crucial for ensuring patient safety. This study highlights the importance of understanding these interactions and the need for personalized treatment approaches. Just as a camel adapts to the changing terrain of the desert, healthcare professionals must be vigilant in monitoring drug interactions and adjusting treatment plans accordingly, ensuring optimal outcomes and patient well-being.

Date :
  1. Date Completed 2013-08-01
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

23636448

DOI: Digital Object Identifier

10.1007/s00280-013-2164-3

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Languages

English

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