Effects of hydrochlorothiazide and amiloride on salt taste and excretion (intake).

Author: ChristensenC M, EngelmanK, MattesR D

Paper Details 
Original Abstract of the Article :
The effects of hydrochlorothiazide (HCTZ) and amiloride on salt excretion (intake) and taste were examined in 73 normotensive adults (aged 18 to 56) who were randomly assigned to receive 50 mg/day of HCTZ (n = 24), 5 mg twice daily of amiloride (n = 24) or placebo (n = 25) for 8 weeks. Two and three...See full text at original site
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引用元:
https://doi.org/10.1093/ajh/3.6.436

データ提供:米国国立医学図書館(NLM)

The Effects of Hydrochlorothiazide and Amiloride on Salt Taste and Excretion

This study investigates the effects of two diuretics, hydrochlorothiazide (HCTZ) and amiloride, on salt excretion and taste perception. Imagine a desert traveler, where thirst is a constant companion, and finding water sources is paramount. This research explores how these medications, which influence fluid balance, affect salt intake and the ability to taste salt.

HCTZ Increases Salt Excretion and Intake

The study found that HCTZ significantly increased sodium excretion and intake, a result that was somewhat surprising. It's like discovering that a well-intended attempt to conserve water in a desert oasis actually leads to an increased need for water. While HCTZ is known to promote sodium excretion, the increased intake observed in the study suggests a more complex interaction between the drug and salt metabolism.

Understanding the Effects of Diuretics on Salt Metabolism

This research provides valuable insights into the effects of diuretics on salt metabolism and taste perception. It highlights the importance of understanding the potential consequences of medication use, especially in relation to dietary habits and individual preferences. It's a reminder that even seemingly simple interventions can have unexpected effects, and careful monitoring and adjustments may be necessary to optimize treatment outcomes.

Dr. Camel's Conclusion

This study underscores the complex interplay between medication, salt metabolism, and taste perception. It's a reminder that even in seemingly simple actions, like taking a medication, there can be intricate and often unexpected consequences. The researchers have shed light on the potential effects of HCTZ and amiloride, emphasizing the importance of considering individual responses and adjusting treatment strategies accordingly.
Date :
  1. Date Completed 1990-08-22
  2. Date Revised 2019-05-10
Further Info :

Pubmed ID

2369494

DOI: Digital Object Identifier

10.1093/ajh/3.6.436

Related Literature

SNS
PICO Info
in preparation
Languages

English

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