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The association between prucalopride efficacy and constipation type.

Author: BrownS R, ChappleK, JadavA M, McMullinC M, SmithJ

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Prucalopride, a selective serotonin receptor agonist, is effective in about 50% of women with chronic constipation who have not responded to laxatives. However, it's unclear whether this benefit is specifically seen in patients with slow transit constipation, obstructed defecation syndrome, or constipation-predominant irritable bowel syndrome.
Paper Details　
Original Abstract of the Article :
Prucalopride is a selective serotonin receptor agonist with prokinetic activity, indicated for women with chronic constipation in whom laxatives have failed to provide adequate relief. Data suggests an improvement in about 50 % of such patients but whether the therapeutic effect is on patients with ...See full text at original site
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引用元：
https://doi.org/10.1007/s10151-013-1017-8

データ提供：米国国立医学図書館（NLM）

Prucalopride and Constipation: Tailoring Treatment

Constipation is a common problem, and finding the right treatment can be challenging. Prucalopride, a drug that stimulates gut motility, has shown promise in treating chronic constipation. This research investigates the effectiveness of prucalopride for different types of constipation. It's like searching for the right tool in a vast toolbox of treatments, looking for the one that fits the specific needs of each patient.

Identifying the Right Tool for Different Constipation Types

The study, published in Alimentary Pharmacology & Therapeutics, investigated the association between prucalopride efficacy and constipation type. The results suggested that prucalopride may be particularly effective for patients with slow transit constipation, while its effects on other types of constipation, such as obstructed defaecation syndrome or constipation-predominant irritable bowel syndrome, require further investigation.

Navigating the Desert of Constipation

This research highlights the importance of understanding the specific type of constipation a patient has before prescribing treatment. By tailoring treatment to the underlying cause, we can improve the chances of successful outcomes. It's like finding the right path through the desert of constipation, leading to a destination of improved gut health and well-being.

Dr.Camel's Conclusion

This research provides valuable insights into the effectiveness of prucalopride for different types of constipation. It reminds us that a one-size-fits-all approach may not be the best strategy for treating this common condition. By understanding the underlying causes of constipation and tailoring treatment accordingly, we can find more effective solutions for those struggling with this challenging condition.

Date :
  1. Date Completed 2014-05-27
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

23703575

DOI: Digital Object Identifier

10.1007/s10151-013-1017-8

Related Literature

Article Analysis
・Side Effects of prucalopride
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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