Effects of torsemide on pharmacodynamics and pharmacokinetics of warfarin in humans and rats.

Author: ChangByung Chul, GwakHye Sun, KimHan Oll, LeeKyung Eun, LeeNa Ra, OhByeou Ree, ParkHee Yoon

Paper Details 
Original Abstract of the Article :
OBJECTIVES: This study aimed to evaluate the effects of torsemide on warfarin therapy in humans and rats. METHODS: For the animal study, rats were orally dosed with warfarin (0.13 mg/kg, control group) or warfarin (0.13 mg/kg) with torsemide (2 mg/kg, low dose group and 10 mg/kg, high dose group). ...See full text at original site
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引用元:
https://doi.org/10.1111/jphp.12084

データ提供:米国国立医学図書館(NLM)

Torsemide and Warfarin: A Complex Interaction in the Realm of Pharmacology

The world of drug interactions can be a complex landscape, much like a desert with shifting sands. This research focuses on the potential interaction between [torsemide and warfarin], two commonly prescribed medications. The researchers used [both animal and human studies] to investigate the effects of [torsemide] on the pharmacodynamics and pharmacokinetics of [warfarin]. They discovered [torsemide significantly lowered stable warfarin doses in humans] indicating a complex interaction between these medications. This study sheds light on the importance of careful monitoring and dose adjustments when patients are taking both [torsemide and warfarin].

Navigating the Interactions: A Balancing Act

This study reveals that [torsemide] can significantly impact the [pharmacodynamics and pharmacokinetics] of [warfarin]. The researchers observed [a significant decrease in the stable warfarin dose in patients taking both medications] suggesting a potentially dangerous interaction. This highlights the critical need for healthcare professionals to be mindful of these interactions and ensure that patients receive appropriate monitoring and dose adjustments.

Safeguarding Patient Health: A Careful Dance in the World of Medications

This research underscores the importance of [understanding the interactions between medications] to ensure patient safety. It's a reminder that even seemingly unrelated medications can interact in unexpected ways, potentially leading to adverse effects. This study emphasizes the need for careful monitoring and dose adjustments, particularly when patients are taking [warfarin and torsemide] together. By recognizing and managing these potential interactions, we can work to safeguard patient health and promote positive treatment outcomes.

Dr. Camel's Conclusion

In the vast expanse of the pharmaceutical world, each medication acts like a distinct star in the night sky, contributing its unique properties. However, just as stars can influence one another through gravitational pull, so too can medications interact in complex ways. This study serves as a guide, shedding light on the potential interactions between [torsemide and warfarin]. By carefully navigating this complex landscape, we can ensure patient safety and maximize the benefits of medication therapies.

Date :
  1. Date Completed 2014-02-21
  2. Date Revised 2018-12-03
Further Info :

Pubmed ID

23837587

DOI: Digital Object Identifier

10.1111/jphp.12084

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Languages

English

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