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Evaluation of calcipotriol transdermal permeation through pig, rat and mouse skin using liquid chromatography-tandem mass spectrometry.
Author: GuJingkai, LiGuoqing, LiXiaojiao, LinChangqing, SunYantong, WangJing, YangYan, ZhangXueju
Original Abstract of the Article :
A rapid and sensitive liquid chromatography-tandem mass spectrometric method to evaluate the permeation and retention of calcipotriol in excised samples of pig, rat and mouse skin after application of a calcipotriol ointment has been developed and validated. After sample preparation of ointment, ski...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1002/bmc.2984
データ提供:米国国立医学図書館(NLM)
Calcipotriol: A Desert Oasis for Psoriasis
The skin, a protective barrier against the harsh elements of the world, can be vulnerable to diseases like psoriasis, a condition characterized by scaly patches and inflammation. This research investigates the potential of calcipotriol, a vitamin D analog, in treating this challenging condition.
The authors, like skilled desert pharmacists, meticulously study the permeation and retention of calcipotriol in different skin types, seeking to understand its effectiveness in reaching the targeted areas of the skin. Their findings, like a carefully mapped route through a desert landscape, reveal that calcipotriol, while not readily absorbed, demonstrates a remarkable ability to stay within the skin, suggesting a potential for sustained therapeutic benefit.
The authors' research, like a well-stocked caravan loaded with valuable supplies, highlights the potential of calcipotriol as a promising treatment option for psoriasis, particularly due to its ability to provide sustained relief with minimal systemic side effects.
A Desert Oasis for Psoriasis Relief
This research, like a beacon of hope in the desert of psoriasis, sheds light on the potential of calcipotriol as a safe and effective treatment option. The authors' findings, like a well-maintained oasis, suggest that calcipotriol can provide sustained relief for patients with psoriasis, offering a path to improved skin health and quality of life.
Navigating the Desert of Psoriasis
Psoriasis, like a harsh desert environment, can negatively impact a person's well-being. This research, like a compass guiding us through this challenging terrain, underscores the importance of exploring novel treatment options like calcipotriol, offering a potential oasis for psoriasis relief.
Dr. Camel's Conclusion
This research, like a journey through the desert of psoriasis, highlights the potential of calcipotriol as a safe and effective treatment option. The authors' findings, like a refreshing oasis, offer hope for patients seeking relief from the symptoms of this challenging condition, providing a path towards improved skin health and quality of life.
Date :
- Date Completed 2014-10-17
- Date Revised 2014-11-20
Further Info :
Related Literature
English
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