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I.V. APD421 (amisulpride) prevents postoperative nausea and vomiting: a randomized, double-blind, placebo-controlled, multicentre trial.

Author: BergisM, BouazizH, ChassardD, DiemunschP, EberhartL, FoxG, GanT J, KehD, KrankeP, LiuN, MotschJ, WallenbornJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

APD421, a D2/D3-antagonist, is being investigated as a potential antiemetic for the prophylaxis of postoperative nausea and vomiting.
Paper Details　
Original Abstract of the Article :
Postoperative nausea and vomiting (PONV) remain significant clinical problems for patients, especially nausea. The D2-antagonist droperidol was popular for prophylaxis until safety concerns limited its use. In early testing, APD421 (amisulpride for i.v. injection), a D2/D3-antagonist, has shown prom...See full text at original site
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引用元：
https://doi.org/10.1093/bja/aet251

データ提供：米国国立医学図書館（NLM）

APD421 (Amisulpride): A New Hope for Postoperative Nausea and Vomiting

Postoperative nausea and vomiting (PONV) is a common and often distressing complication, leaving patients feeling like they are navigating a turbulent sea of discomfort. This study investigates the potential of APD421 (amisulpride for intravenous injection), a D2/D3-antagonist, as a prophylactic treatment for PONV. The researchers conducted a randomized, double-blind, dose-finding study to assess the effectiveness of APD421 in preventing PONV, seeking a safe and effective solution for this common post-surgical challenge.

Amisulpride: A Potential New Antiemetic

The study found that APD421 was effective in preventing postoperative nausea and vomiting, providing a potential new option for patients at risk for this common complication. The results are promising, offering hope for a new and potentially more effective approach to managing PONV, particularly in patients who may experience side effects with other antiemetics. This research is like a lifeboat, offering a new and potentially safer way to navigate the choppy waters of postoperative nausea and vomiting.

Easing Postoperative Discomfort: A New Horizon

This study, like a beacon of hope in the turbulent seas of postoperative discomfort, suggests that APD421 may offer a new and effective approach to preventing PONV. The findings highlight the potential for this medication to improve patient recovery and reduce the burden of this common complication. This research is a testament to the ongoing quest for better and safer treatments, paving the way for a smoother and more comfortable post-surgical experience for patients.

Dr.Camel's Conclusion

This study, like a skilled navigator charting a course through the stormy seas of postoperative nausea and vomiting, explores the potential of APD421 (amisulpride) as a safe and effective prophylactic treatment. The findings offer hope for a new and promising approach to managing this common complication, potentially improving patient recovery and reducing the burden of postoperative discomfort. This research is a beacon of hope, illuminating a new horizon in the fight against PONV.

Date :
  1. Date Completed 2014-01-20
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

23872464

DOI: Digital Object Identifier

10.1093/bja/aet251

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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