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Sustained-release fampridine (4-aminopyridine) in multiple sclerosis: efficacy and impact on motor function.

Author: KreymborgKimberly, RabadiMeheroz H, VincentAndrea S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Dalfampridine improved walking speed and endurance in veterans with multiple sclerosis (MS) with limited ambulation.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: The aim of this study was to determine the efficacy of sustained-release fampridine (4-aminopyridine) in veterans with multiple sclerosis (MS) with limited ambulatory ability, and its impact on motor function in an outpatient setting. DESIGN: Retrospective. SETTING: Tertiary referral ce...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784065/

データ提供：米国国立医学図書館（NLM）

Improving Mobility for Multiple Sclerosis Patients

This study delves into the crucial area of multiple sclerosis (MS) treatment. It aims to examine the effectiveness of sustained-release fampridine (4-aminopyridine) in veterans with MS who have difficulty walking. The researchers utilized a retrospective design and analyzed data from a tertiary referral center. The study focused on 20 MS patients who were prescribed dalfampridine due to their walking challenges. The primary outcome measures included changes in walking speed, distance, and functional independence. The researchers discovered that dalfampridine led to significant improvements in walking speed and endurance, indicating clinically meaningful benefits for these individuals.

Positive Outcomes for MS Patients

The results suggest a positive impact of dalfampridine treatment on MS patients with limited ambulation. The observed improvement in walking speed and endurance, along with a significant change in motor function, signifies a potential breakthrough in managing the debilitating effects of MS. This study's findings underscore the importance of exploring new therapeutic options for improving mobility in MS patients.

Implications for Daily Life

This research highlights the potential benefits of dalfampridine for individuals living with MS and facing mobility challenges. It suggests that this medication could help improve their quality of life by enabling them to participate more actively in daily activities.

Dr.Camel's Conclusion

As a fellow researcher, I'm excited by the prospect of dalfampridine's positive impact on MS patients. Its ability to improve walking speed and endurance, not just for the sake of mobility, but also to enhance functional independence, resonates deeply. This research is a testament to the enduring pursuit of better treatments for debilitating diseases, and it's a reminder that even a small improvement in quality of life can have a profound impact.
Date :
  1. Date Completed 2014-04-28
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

23873597

DOI: Digital Object Identifier

PMC3784065

Related Literature

Article Analysis
・Effects of dalfampridine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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