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Effects of ospemifene on drug metabolism mediated by cytochrome P450 enzymes in humans in vitro and in vivo.

Author: KailajärviMarita, LammintaustaRisto, LehtinenTerhi, PelkonenOlavi, ScheininMika, StjernschantzCamilla, TapanainenPasi, TurpeinenMiia, UusitaloJouko, VuorinenJouni

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Ospemifene, a selective estrogen receptor modulator, is unlikely to significantly affect the metabolism of drugs that are substrates for CYP enzymes. It weakly inhibits CYP enzymes in vitro, but these effects are not observed at clinically relevant concentrations.
Paper Details　
Original Abstract of the Article :
The objective of these investigations was to determine the possible effects of the novel selective estrogen receptor modulator, ospemifene, on cytochrome P450 (CYP)-mediated drug metabolism. Ospemifene underwent testing for possible effects on CYP enzyme activity in human liver microsomes and in iso...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742231/

データ提供：米国国立医学図書館（NLM）

Ospemifene: A Promising New Estrogen Modulator

This study investigates the potential effects of [ospemifene] on [drug metabolism] mediated by [cytochrome P450 enzymes] in humans. Imagine a vast desert landscape, where [drug metabolism] is like a complex network of rivers and streams, processing and eliminating medications from the body. Ospemifene is like a new irrigation system, potentially influencing the flow of these metabolic pathways.

Understanding Ospemifene's Impact on Drug Metabolism

The study explored the effects of [ospemifene] on a variety of [CYP enzymes], finding that it had a [weak inhibitory effect] on several of these enzymes. However, the researchers concluded that the risk of [ospemifene affecting the pharmacokinetics of other drugs] was low, based on the results of both [in vitro and in vivo studies].

Ospemifene: A Valuable Tool in the Healthcare Landscape

This study provides valuable insights into the [pharmacokinetic profile] of [ospemifene], highlighting its potential as a [safe and effective treatment] for certain conditions. The findings suggest that [ospemifene] can be used with confidence, with a low risk of [drug interactions] with other medications.

Dr. Camel's Conclusion

This study, like a carefully crafted map of a vast desert, guides us through the intricate landscape of [drug metabolism]. It provides valuable information about the potential effects of [ospemifene] on [CYP enzymes], reassuring healthcare professionals and patients alike about its [safety and efficacy].
Date :
  1. Date Completed 2014-02-11
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

23880855

DOI: Digital Object Identifier

PMC3742231

Related Literature

Article Analysis
・Effects of ospemifene
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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