Topotecan plus cyclophosphamide as maintenance chemotherapy for children with high-risk neuroblastoma in complete remission: short-term curative effects and toxicity.

Author: FengChen, LiuYing, TangSuoqin, WangJianwen, YangGuang

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To evaluate chemotherapy-related toxicity and the short-term efficacy of topotecan and cyclophosphamide as maintenance chemotherapy for stage IV neuroblastoma in complete remission. METHODS: The clinical data of 16 children with stage IV neuroblastoma received 3 cycles of maintenance che...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/23996746

データ提供:米国国立医学図書館(NLM)

Topotecan Plus Cyclophosphamide for Neuroblastoma Maintenance: A Promising Approach

Neuroblastoma, a type of cancer that affects the nervous system, can be a challenging foe, especially in children. This study investigates the effectiveness of [topotecan plus cyclophosphamide] as [maintenance chemotherapy] for children with [high-risk neuroblastoma] who have achieved complete remission. The researchers analyzed data from 16 children and found that [the combination therapy was effective in maintaining remission], with a [two-year event-free survival rate of 68.75%]. The study also noted that [the most common side effect was bone marrow suppression]. This research provides encouraging evidence for the potential of this combination therapy in managing high-risk neuroblastoma.

Topotecan Plus Cyclophosphamide: A New Weapon in the Fight Against Neuroblastoma

This study offers a glimmer of hope for children with high-risk neuroblastoma. The findings suggest that topotecan plus cyclophosphamide could be a valuable tool in maintaining remission, providing a potential pathway for long-term survival for patients. This research could lead to improved outcomes and a better quality of life for children battling this challenging disease.

Navigating the Desert of Neuroblastoma Treatment: Finding New Oases of Hope

This study underscores the importance of continued research and development in the fight against neuroblastoma. The findings suggest that topotecan plus cyclophosphamide could be a promising treatment option for high-risk neuroblastoma, offering a beacon of hope in the desert of childhood cancer treatment. It's a testament to the dedication of researchers who are constantly striving for new ways to improve outcomes and make the journey through cancer treatment a little less challenging.

Dr. Camel's Conclusion

This research explores the potential of topotecan plus cyclophosphamide as a maintenance chemotherapy for high-risk neuroblastoma, demonstrating its effectiveness in maintaining remission and achieving a significant event-free survival rate. The desert of childhood cancer treatment is vast and challenging, but research like this provides a beacon of hope, guiding us towards more effective therapies and a brighter future for children battling this disease.

Date :
  1. Date Completed 2014-07-24
  2. Date Revised 2013-09-02
Further Info :

Pubmed ID

23996746

DOI: Digital Object Identifier

23996746

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