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Functional genetic polymorphisms in CYP2C19 gene in relation to cardiac side effects and treatment dose in a methadone maintenance cohort.

Author: ChangYao-Sheng, ChenAndrew C H, ChenChia-Hui, HoIng-Kang, HsiaoChin-Fu, HuangChieh-Liang, KuoHsiang-Wei, LinKeh-Ming, LinLinen, LiuMing-Lun, LiuSheng-Wen, LiuShu Chih, LiuYu-Li, SuLien-Wen, TanHappy Kuy-Lok, TsouHsiao-Hui, WangSheng-Chang, WuChi-Shin, WuHsiao-Yu, YangYi-Hong

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study explored the impact of CYP2C19 gene polymorphisms on methadone maintenance therapy, specifically investigating their influence on dosage, plasma concentration, and side effects. The results suggest that CYP2C19 genetic variations may influence methadone dosage requirements, plasma concentrations, and cardiac side effects, particularly in patients who continue using heroin.
Paper Details　
Original Abstract of the Article :
Abstract Methadone maintenance therapy is an established treatment for heroin dependence. This study tested the influence of functional genetic polymorphisms in CYP2C19 gene encoding a CYP450 enzyme that contributes to methadone metabolism on treatment dose, plasma concentration, and side effects of...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783925/

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 2014-04-17
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24016178

DOI: Digital Object Identifier

PMC3783925

Related Literature

Article Analysis
・Side Effects of methadone
SNS
PICO Info
in preparation
Languages

English

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