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In vitro antibacterial activity of some antihistaminics belonging to different groups against multi-drug resistant clinical isolates.

Author: Abou-ShleibHamida M, El-HalfawyOmar M, El-NakeebMoustafa A, KhalilAmal M, OmarHoda G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigates the antimicrobial activity of 10 antihistaminics against multiresistant Gram-positive and Gram-negative clinical isolates. The results demonstrate that some antihistaminics, such as azelastine, cyproheptadine, mequitazine, and promethazine, possess significant antimicrobial activity, while others exhibit weaker or no activity.
Paper Details　
Original Abstract of the Article :
Antihistaminics are widely used for various indications during microbial infection. Hence, this paper investigates the antimicrobial activities of 10 antihistaminics belonging to both old and new generations using multiresistant Gram-positive and Gram-negative clinical isolates. The bacteriostatic a...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768775/

データ提供：米国国立医学図書館（NLM）

Antihistaminics: More Than Just Allergy Relief?

This study investigates the potential antibacterial activity of antihistamines, medications commonly used for treating allergies. The research explores the antimicrobial effects of 10 antihistamines from different generations against multi-drug resistant clinical isolates of bacteria. The researchers evaluated the bacteriostatic activity of these antihistamines using broth and agar dilution techniques.

Some Antihistamines Show Antibacterial Activity

The study found that certain antihistamines, including azelastine, cyproheptadine, mequitazine, and promethazine, exhibited significant antibacterial activity against various multi-drug resistant bacteria. These findings suggest that these antihistamines may have broader therapeutic potential beyond their traditional use in allergy management.

A New Perspective on Antihistamine Therapy

This study broadens our understanding of the potential therapeutic applications of antihistamines. The research suggests that these medications may offer additional benefits, such as antibacterial activity. This opens up new avenues for exploring the potential of antihistamines in managing infections, potentially complementing or even replacing antibiotics in certain situations.

Dr. Camel's Conclusion

This research delves into the surprising antibacterial properties of some antihistamines. It opens up new horizons in our understanding of these medications, revealing their potential as multi-purpose therapeutic agents. The findings inspire further research into the antibacterial effects of antihistamines, potentially leading to novel treatment approaches for infections.
Date :
  1. Date Completed 2013-09-13
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24031715

DOI: Digital Object Identifier

PMC3768775

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Languages

English

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