The pharmacokinetics and safety profiles of belimumab after single subcutaneous and intravenous doses in healthy Japanese volunteers.

Author: EndoA, HiramaT, InoH, SakamotoT, ShidaY, TakahashiN

Paper Details 
Original Abstract of the Article :
Belimumab is a recombinant human monoclonal antibody that binds and antagonizes the biological activity of soluble B-lymphocyte stimulator (BLyS) protein. BLyS appears to play a role in the pathogenesis of systemic lupus erythematosus, and the biological profile of belimumab suggests that it may hav...See full text at original site
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引用元:
https://doi.org/10.1111/jcpt.12101

データ提供:米国国立医学図書館(NLM)

Belimumab: Investigating Pharmacokinetics and Safety in Japanese Volunteers

Belimumab is a promising monoclonal antibody used to treat systemic lupus erythematosus (SLE), a chronic autoimmune disease. This research investigates the pharmacokinetics and safety profile of belimumab after single subcutaneous and intravenous doses in healthy Japanese volunteers. It's like a camel caravan meticulously studying a new desert route, ensuring safety and efficiency before embarking on a long journey.

Evaluating the Pharmacokinetic Profile of Belimumab

The study analyzed the pharmacokinetic profile of belimumab, examining how it is absorbed, distributed, metabolized, and eliminated in the body. This information is crucial for optimizing dosage and ensuring safe and effective treatment. It's like carefully mapping a desert route, understanding the terrain and resources available to ensure a successful journey.

Safety First: A Crucial Aspect of Drug Development

The study also focused on the safety profile of belimumab, evaluating potential adverse effects in the volunteers. This is a critical aspect of drug development, ensuring that the benefits outweigh the risks. It's like inspecting a caravan's supplies before setting out, ensuring the safety and well-being of the travelers.

Dr.Camel's Conclusion

This study provides valuable insights into the pharmacokinetics and safety profile of belimumab in Japanese volunteers. This information is essential for optimizing treatment strategies and ensuring the safe and effective use of this promising drug for SLE. It's like meticulously mapping a desert route, ensuring a safe and successful journey for those seeking relief from the challenges of SLE.

Date :
  1. Date Completed 2014-09-28
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

24117862

DOI: Digital Object Identifier

10.1111/jcpt.12101

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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