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Synthesis and characterization of quinazoline derivatives: search for hybrid molecule as diuretic and antihypertensive agents.
Author: Mujeeb Ur Rahman, ParveenGazala, RathoreAnkita, SiddiquiAnees A, YarM Shahar
Original Abstract of the Article :
To explore the pharmacological and structure-activity relationship of a series of N-substituted-(4-oxo-2-substituted-phenylquinazolin-3-(4H)-yl), substituted benzene sulfonamide derivatives (1-25) were synthesized from substituted anthranilic acids derived amino quinazolines and substituted benzene ...See full text at original site
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引用元：
https://doi.org/10.3109/14756366.2013.845820
データ提供：米国国立医学図書館（NLM）
Quinazoline Derivatives: A Search for New Desert Treasures
The search for new and effective therapeutic agents is a constant endeavor, much like a tireless explorer seeking hidden treasures in a vast desert. This research explores the synthesis and characterization of a series of quinazoline derivatives, seeking to develop novel compounds with diuretic and antihypertensive properties. The researchers synthesized a range of N-substituted-(4-oxo-2-substituted-phenylquinazolin-3-(4H)-yl), substituted benzene sulfonamide derivatives and evaluated their diuretic, antihypertensive, and antidiabetic potential in rats. Their findings revealed that several compounds exhibited significant activity, demonstrating the potential of quinazoline derivatives as promising drug candidates.
Quinazoline Derivatives: A Potential New Frontier in Drug Discovery
The study identified compound N-[7-chloro-2-(4-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl]-4 nitrobenzenesulfonamide (20) as the most potent compound in the series, exhibiting significant diuretic and antihypertensive activity. This finding highlights the potential of quinazoline derivatives as a promising new class of therapeutic agents for managing various health conditions.
Navigating the Desert of Drug Discovery
The search for new and effective drugs is a constant journey through the vast desert of medical research. This research provides valuable insights into the potential of quinazoline derivatives as promising drug candidates, highlighting the need for further investigation and clinical trials to confirm their efficacy and safety in humans.
Dr.Camel's Conclusion
This research offers a promising new avenue for drug discovery, highlighting the potential of quinazoline derivatives as effective diuretic and antihypertensive agents. This study paves the way for further research and development of these compounds as potential new treatments for various health conditions.
Date :
- Date Completed 2015-03-12
- Date Revised 2014-09-11
Further Info :
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