Paper Details

  1. Home
  2. Paper Details

Effects of rasagiline on olfactory function in patients with Parkinson’s disease.

Author: FauserMareike, HaehnerAntje, HummelThomas, KlingelhöferLisa, ReichmannHeinz, StorchAlexander, WolzMartin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A randomized controlled trial of 34 patients with Parkinson’s disease found no significant difference in olfactory function between patients treated with rasagiline, a MAO-B inhibitor, and those treated with placebo. The study did not reach the primary endpoint and therefore could not demonstrate a specific effect of rasagiline on olfaction in PD patients.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Impairment of olfactory function is a well recognized nonmotor manifestation of Parkinson’s disease(PD). The aim of this investigation was to determine if the MAO-B inhibitor rasagiline can improve olfaction in PD patients. METHODS: Thirty-four PD patients participated in this single-ce...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1002/mds.25661

データ提供：米国国立医学図書館（NLM）

Rasagiline: A Potential Treatment for Olfactory Dysfunction in Parkinson’s Disease?

This study delves into the potential of rasagiline, a monoamine oxidase-B (MAO-B) inhibitor, to improve olfactory function in patients with Parkinson's disease (PD). Olfactory impairment is a common non-motor symptom of PD. The researchers conducted a randomized, controlled, double-blind study involving 34 PD patients, comparing the effects of rasagiline to placebo over 120 days. The study findings revealed no significant difference in olfactory function between the two groups after 120 days of treatment.

Exploring the Link Between Rasagiline and Olfactory Function in PD

The research explores the potential of rasagiline to address olfactory dysfunction in PD, a debilitating symptom that can significantly impact quality of life. While the study did not demonstrate a significant effect of rasagiline on olfactory function, further research is needed to fully understand the role of MAO-B inhibitors in managing this aspect of PD.

Seeking Solutions for Olfactory Dysfunction in PD

This study highlights the importance of ongoing research to develop effective treatments for olfactory dysfunction in PD.

Dr. Camel's Conclusion

Parkinson's disease can be a challenging journey, often accompanied by a loss of smell, like a desert losing its fragrant winds. While this research didn't find conclusive evidence that rasagiline improves olfactory function, it underscores the need for further exploration, hoping to find a way to restore the lost scents of life for those living with PD.

Date :
  1. Date Completed 2014-07-29
  2. Date Revised 2014-01-25
Further Info :

Pubmed ID

24190245

DOI: Digital Object Identifier

10.1002/mds.25661

Related Literature

Article Analysis
・Effects of rasagiline
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.