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Use of buccal micronucleus assay to determine mutagenicity induced by amfepramone in humans and the protective effects of vitamin C.
Author: Moysés ReyesJuliana, Silva KahlVívian Francília, Silva NunesMarisa Fernanda da, da SilvaJuliana, da Silva NunesRoberta
Original Abstract of the Article :
The abusive use of amfepramone in Brazilian population has grown in recent years. Few studies have been conducted on amphetamine with respect to DNA damage, and there have been no apparent investigations examining the influence of amfepramone on humans. The aim of this study was to determine the pos...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://doi.org/10.1080/15287394.2013.841533
データ提供：米国国立医学図書館（NLM）
Amfepramone: A Potential Desert Storm in DNA Damage
The world of health is constantly seeking to understand the potential dangers of various substances, particularly those that are abused or used for non-medical purposes. This research explores the potential mutagenic effects of amfepramone, a stimulant drug that is sometimes abused. The authors conducted a study using the micronucleus (MN) assay to assess the potential DNA damage caused by amfepramone in humans.
The study aimed to determine if amfepramone could induce DNA damage, leading to potential mutations. They compared the frequency of MN in individuals using amfepramone to a control group, and they also investigated the potential protective effects of vitamin C.
Amfepramone: A Warning Sign in the Desert of DNA Damage
The study found that amfepramone use was associated with a significant increase in MN, indicating DNA damage. It’s like a desert storm, potentially wreaking havoc on the delicate balance of DNA. The study highlights the potential genotoxic effects of amfepramone, suggesting that it could pose a risk to human health.
Navigating the Desert of Substance Abuse: A Call for Caution
This research underscores the importance of understanding the potential health risks associated with substance abuse, especially those that can cause DNA damage. It’s like navigating a dangerous desert landscape, where exposure to harmful substances can lead to serious consequences. The authors suggest that individuals should be aware of the potential risks of amfepramone use and that further research is needed to fully understand its long-term effects on human health.
Dr. Camel's Conclusion
This study is like a warning sign in the desert of substance abuse, highlighting the potential dangers of amfepramone. It underscores the importance of understanding the potential genotoxic effects of drugs and the need for caution when using substances that could harm human health.
Date :
- Date Completed 2014-01-17
- Date Revised 2013-11-26
Further Info :
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