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Lorcaserin and pimavanserin: emerging selectivity of serotonin receptor subtype-targeted drugs.

Author: MeltzerHerbert Y, RothBryan L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review provides an overview of serotonin (5-HT) receptor pharmacology, focusing on the roles of 5-HT receptors in various physiological functions and neuropsychiatric disorders. It also discusses two recent subtype-selective drugs: lorcaserin (targets 5-HT2C) for obesity and pimavanserin (targets 5-HT2A) for Parkinson's disease psychosis.
Paper Details　
Original Abstract of the Article :
Serotonin (5-hydroxytryptamine, or 5-HT) receptors mediate a plethora of physiological phenomena in the brain and the periphery. Additionally, serotonergic dysfunction has been implicated in nearly every neuropsychiatric disorder. The effects of serotonin are mediated by fourteen GPCRs. Both the the...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859385/

データ提供：米国国立医学図書館（NLM）

Serotonin Receptor Targeting: A Camel's Guide to New Drugs

Serotonin (5-HT) receptors play a crucial role in a wide array of physiological processes, from mood regulation to appetite control. Dysfunction in the serotonergic system is implicated in various neuropsychiatric disorders. This review explores the emerging field of serotonin receptor subtype-targeted drugs, focusing on two recent examples: lorcaserin and pimavanserin. These drugs demonstrate selective targeting of specific 5-HT receptor subtypes, offering new therapeutic avenues for conditions like obesity and Parkinson's disease psychosis.

Selective Targeting: A Promising Avenue for Drug Development

The development of drugs that selectively target specific serotonin receptor subtypes presents a promising approach to drug development. This review highlights the potential of this strategy to improve therapeutic efficacy while minimizing unwanted side effects. Lorcaserin and pimavanserin showcase the benefits of this approach, offering hope for more effective and targeted treatments for a variety of conditions.

Serotonin: A Key Player in Our Brain's Symphony

Serotonin is a vital neurotransmitter, playing a crucial role in regulating mood, appetite, sleep, and many other bodily functions. This review underscores the importance of understanding the complex interplay of serotonin receptors and their potential for therapeutic targeting. By unraveling the mysteries of the serotonergic system, we can pave the way for more effective and safe treatments for a wide range of conditions.

Dr.Camel's Conclusion

The field of serotonin receptor subtype-targeted drugs is a burgeoning desert, full of promise. This review provides a valuable overview of the potential benefits of this approach, highlighting the progress made with lorcaserin and pimavanserin. As our understanding of the serotonergic system continues to grow, we can expect to see even more innovative and targeted treatments emerge, offering hope for a brighter future for those battling neuropsychiatric disorders.

Date :
  1. Date Completed 2014-02-04
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24292660

DOI: Digital Object Identifier

PMC3859385

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・Side Effects of pimavanserin
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PICO Info
in preparation
Languages

English

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