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Bexarotene nanocrystal-Oral and parenteral formulation development, characterization and pharmacokinetic evaluation.

Author: ChenLijiang, GuoHejian, HaoLeilei, LouHongxiang, WangYongjie, ZhangDianrui, ZhangJiaozhen

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the use of nanocrystals to enhance the bioavailability of bexarotene, a retinoid drug used for cancer treatment. Oral and intravenous nanocrystals were found to improve bexarotene's bioavailability and potentially reduce side effects.
Paper Details　
Original Abstract of the Article :
Bexarotene (Targretin®) is a synthetic retinoid that selectively activates the retinoid X receptor subfamily of retinoid receptors and exhibits potent anti-tumor activity. However, the poor solubility and bioavailability limit its application. The main aim of this study is to investigate the potenti...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejpb.2013.12.005

データ提供：米国国立医学図書館（NLM）

Bexarotene Nanocrystals: Enhancing Bioavailability and Reducing Side Effects

Bexarotene, a retinoid with potent anti-tumor activity, has limited clinical application due to its poor solubility and bioavailability. This study explores the potential of nanocrystal formulation to enhance bexarotene's bioavailability and reduce its side effects. The researchers investigated both oral and parenteral nanocrystals, demonstrating a significant increase in in vitro dissolution rate and improved pharmacokinetic profiles in rats. This innovative approach offers a promising strategy for overcoming the limitations of bexarotene therapy.

Nanocrystal Formulation: A Breakthrough for Bexarotene Delivery

This study highlights the potential of nanocrystal formulation as a groundbreaking solution for improving the bioavailability of bexarotene. The researchers have successfully demonstrated that both oral and parenteral nanocrystals significantly enhance bexarotene's absorption and reduce its side effects. This innovative approach offers a promising path towards more effective and well-tolerated bexarotene therapy.

The Future of Bexarotene Therapy: A Focus on Nanocrystal Formulation

This research paves the way for a new era in bexarotene therapy, leveraging the power of nanocrystal formulation to overcome the limitations of this potent anti-tumor agent. The study's findings suggest that nanocrystal formulation can significantly enhance bioavailability, reduce side effects, and improve the overall efficacy of bexarotene treatment. This innovative approach holds the potential to transform the way we deliver and manage bexarotene therapy in the future.

Dr.Camel's Conclusion

Like a desert traveler finding a hidden spring of fresh water, this research offers a promising solution to the challenges of bexarotene delivery. The researchers have successfully harnessed the power of nanocrystal formulation to enhance bioavailability and reduce side effects, paving the way for a more effective and well-tolerated treatment approach. This groundbreaking research has the potential to dramatically impact the future of bexarotene therapy, offering hope for improved outcomes for patients battling cancer.
Date :
  1. Date Completed 2015-01-13
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

24333772

DOI: Digital Object Identifier

10.1016/j.ejpb.2013.12.005

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in preparation
Languages

English

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