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Increase in medial frontal cortex ERK activation following the induction of apomorphine sensitization.

Author: BloiseEnrrico, CareyRobert J, CarreraMarinete Pinheiro, CespedesIsabel Cristina, DiasFlávia Regina Cruz, Giraldi-GuimarãesArthur, SamuelsRichard Ian, SanguedoFrederico Velasco Costa

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Repeated high-dose injections of apomorphine, a D1/D2 agonist, induce behavioral sensitization. Five daily injections significantly increased locomotor activity in rats, suggesting sensitization. ERK activity in the medial prefrontal cortex (PFC) increased after repeated injections, indicating a possible role in sensitization.
Paper Details　
Original Abstract of the Article :
Repeated high dose injections of the direct acting D1/D2 agonist apomorphine (APO) induces context specific behavioral sensitization. We assessed the effects of 2.0 mg/kg APO on open-field locomotor responses of rats over a 30 min period following either single or five daily APO injections. Acute in...See full text at original site
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引用元：
https://doi.org/10.1016/j.pbb.2013.12.020

データ提供：米国国立医学図書館（NLM）

Apomorphine Sensitization and ERK Activation: A Journey Through the Dopamine Desert

Apomorphine is a dopamine agonist, a medication that stimulates dopamine receptors in the brain. Repeated exposure to high doses of apomorphine can lead to behavioral sensitization, characterized by an exaggerated response to the drug over time. This study investigates the neural mechanisms underlying this sensitization, focusing on the role of ERK, a protein involved in cellular signaling pathways.

Increased ERK Activity in the Medial Frontal Cortex

The study examined the effects of repeated apomorphine injections on the activity of ERK in different brain regions. The researchers found that repeated apomorphine injections significantly increased ERK activity in the medial frontal cortex (PFC), a brain region involved in cognitive control and decision-making. This finding suggests that ERK activation in the PFC might play a crucial role in mediating the development of apomorphine sensitization.

Understanding the Neural Basis of Sensitization

This research provides valuable insights into the neural mechanisms underlying drug sensitization, a phenomenon that can contribute to addiction and other behavioral problems. Just as a camel navigates the desert landscape, researchers are exploring the intricate pathways within the brain to understand how drugs affect behavior. This knowledge is essential for developing effective strategies to prevent and treat addiction, helping individuals to overcome the challenges associated with substance abuse.

Dr. Camel's Conclusion

This study delves into the fascinating world of dopamine and its role in the development of drug sensitization. The findings highlight the importance of understanding the complex interplay between neural signaling pathways and behavior. This research is a crucial step towards developing more effective treatments for addiction and other behavioral disorders, helping individuals to break free from the grip of substance abuse and find a path to recovery.

Date :
  1. Date Completed 2014-11-04
  2. Date Revised 2014-02-17
Further Info :

Pubmed ID

24380761

DOI: Digital Object Identifier

10.1016/j.pbb.2013.12.020

Related Literature

Article Analysis
・Effects of apomorphine injection
SNS
PICO Info
in preparation
Languages

English

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