Infections during peginterferon/ribavirin therapy are associated with the magnitude of decline in absolute lymphocyte count: results of the IDEAL study.

Author: BrassClifford A, BräuNorbert, GallerGreg W, LawitzEric J, LeeWilliam M, LongJianmin, McHutchisonJohn G, MeliaMichael T, MuirAndrew J, NovielloStephanie, NybergLisa M, PediconeLisa D, PoordadFred, SchiffEugene, ShiffmanMitchell L, SulkowskiMark S

Paper Details 
Original Abstract of the Article :
Myelosuppression due to pegylated interferon (peg-IFN) is common during treatment for hepatitis C virus. The relationship between infection risk and decreases in leukocyte lines, however, is not well established. The objective of this analysis was to determine the incidence of and risk factors for i...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3968310/

データ提供:米国国立医学図書館(NLM)

Infections During Peginterferon/Ribavirin Therapy

This research ventures into the challenging landscape of hepatitis C treatment, examining the relationship between infections and myelosuppression during peginterferon (peg-IFN)/ribavirin (RBV) therapy. The study investigates the incidence of and risk factors for infections during peg-IFN/RBV therapy, focusing on the impact of decreases in absolute lymphocyte count. The researchers analyzed data from the IDEAL study, discovering that infections during peg-IFN/RBV therapy are associated with the magnitude of decline in absolute lymphocyte count. This research highlights the importance of monitoring lymphocyte counts during peg-IFN/RBV therapy, identifying individuals at increased risk of infection and implementing appropriate preventive measures to mitigate this risk.

The Importance of Monitoring Lymphocyte Counts

The study's findings underscore the importance of monitoring lymphocyte counts during peg-IFN/RBV therapy, particularly in individuals with a significant decline in absolute lymphocyte count. This monitoring can help identify individuals at increased risk of infection, enabling healthcare providers to implement appropriate preventive measures to protect patients and minimize the risk of complications. This research emphasizes the importance of personalized care in managing hepatitis C, tailoring treatment strategies to the unique needs of each patient.

Navigating the Challenges of Hepatitis C Treatment

This research provides valuable insights into the challenges of hepatitis C treatment, particularly the risk of myelosuppression and associated infections. The study's findings highlight the need for comprehensive patient monitoring, individualized treatment plans, and effective infection prevention strategies to optimize treatment outcomes and minimize complications for patients with hepatitis C. This research underscores the importance of ongoing research to develop safer and more effective therapies for managing this complex and often debilitating condition.

Dr.Camel's Conclusion

This research is like a camel caravan navigating a treacherous desert, seeking safe passage through the challenging terrain of hepatitis C treatment. The study's findings emphasize the importance of monitoring lymphocyte counts to identify individuals at risk of infection, ensuring that patients receive personalized care and effective infection prevention strategies. This journey through the desert of hepatitis C management underscores the importance of ongoing research to develop safer and more effective therapies, offering hope for a future where this condition is effectively managed and its impact minimized.

Date :
  1. Date Completed 2015-05-28
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24399086

DOI: Digital Object Identifier

PMC3968310

Related Literature

SNS
PICO Info
in preparation
Languages

English

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