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Safety and efficacy of tolcapone in the long-term use in Parkinson disease: an observational study.

Author: , EggertKarla, LeesAndrew J, OertelWolfgang H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Tolcapone was found to be safe and effective in patients with Parkinson disease. Significant liver transaminase elevations were rare and generally returned to normal without intervention.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: The aim of this observational study was to investigate the safety and efficacy of tolcapone under practice conditions. METHODS: This 12-month non-interventional study was conducted from November 2005 to August 2009. Safety parameters were incidence of adverse drug reactions (ADRs), sign...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/24434524

データ提供：米国国立医学図書館（NLM）

Tolcapone: A Long-Term Solution for Parkinson's Disease

Parkinson's disease, a neurodegenerative disorder, presents a significant challenge for patients and their families. This observational study investigated the safety and efficacy of tolcapone, a medication used to treat Parkinson's disease, in long-term use under routine practice conditions.

Tolcapone: Safe and Effective in Long-Term Use

The study found that tolcapone was generally safe and effective in patients with Parkinson's disease, with a low risk of hepatotoxicity. While some patients experienced elevations in liver enzymes, these were typically mild and reversible. The physicians reported improvement in the clinical global impression for the majority of patients, suggesting the long-term efficacy of tolcapone in managing Parkinson's symptoms.

Navigating the Desert of Parkinson's

This study provides valuable insight into the long-term use of tolcapone in treating Parkinson's disease. Understanding the safety and efficacy of medications is crucial for navigating the complexities of this condition and ensuring optimal patient outcomes.

Dr. Camel's Conclusion

This study offers a glimmer of hope in the desert of Parkinson's disease. Tolcapone, like a sturdy camel, provides reliable support in the long-term management of this debilitating condition. Its safety and efficacy, coupled with the availability of effective monitoring strategies, provide patients with a valuable tool for improving their quality of life.

Date :
  1. Date Completed 2014-09-11
  2. Date Revised 2018-12-03
Further Info :

Pubmed ID

24434524

DOI: Digital Object Identifier

00002826-201401000-00001

Related Literature

Article Analysis
・Side Effects of tolcapone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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