Weight change and metabolic effects of asenapine in patients with schizophrenia and bipolar disorder.

Author: CazorlaPilar, KempDavid E, LandbloomRonald P, MackleMary, Snow-AdamiLinda, SzegediArmin, ZhaoJun

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To describe weight changes and metabolic effects of asenapine compared with placebo and olanzapine in adults. METHOD: Post hoc analyses were performed using data from 17 asenapine trials (13 schizophrenia and 4 bipolar mania trials) with placebo (5-10 mg twice daily; n = 1,748; 1-6 weeks...See full text at original site
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引用元:
https://doi.org/10.4088/JCP.12m08271

データ提供:米国国立医学図書館(NLM)

Asenapine and Metabolic Effects: A Balancing Act

[Antipsychotic medications] are crucial for managing [schizophrenia] and [bipolar disorder]. This study investigates the metabolic effects of [asenapine], a medication commonly used in these conditions. The researchers analyzed data from several clinical trials to compare the weight changes and metabolic effects of asenapine with those of [placebo] and [olanzapine], another antipsychotic medication. The aim was to assess the metabolic impact of asenapine in the context of these other treatment options.

Weighing the Pros and Cons: Metabolic Effects of Asenapine

The study revealed that asenapine led to greater weight gain compared to placebo. However, the weight gain associated with asenapine was significantly lower compared to olanzapine. The findings also showed that asenapine had a smaller impact on [fasting glucose levels] and [cholesterol levels] than olanzapine. These results suggest that asenapine might be a more favorable option in terms of metabolic effects, offering a potential balance between efficacy and metabolic side effects.

Balancing Mental Health and Metabolic Well-being

This study emphasizes the importance of considering the metabolic implications of [antipsychotic medications]. While these medications are essential for managing [schizophrenia] and [bipolar disorder], they can have significant metabolic side effects. The findings highlight the need for careful monitoring and management of weight gain, glucose levels, and lipid levels in patients taking antipsychotic medications, particularly those with pre-existing metabolic conditions.

Dr. Camel's Conclusion

This study sheds light on the intricate relationship between [antipsychotic medications] and metabolic health, much like the delicate balance between the shifting sands and the hardy plants that thrive in the desert. While these medications provide valuable relief, they can also come with metabolic side effects. The findings urge us to tread carefully, weighing the benefits of these medications against their potential metabolic impact.

Date :
  1. Date Completed 2014-06-10
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

24499969

DOI: Digital Object Identifier

10.4088/JCP.12m08271

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