Paper Details 
Original Abstract of the Article :
The combined use of the histone deacetylase inhibitor valproic acid (VPA), the retinoic acid receptor- α agonist all-trans retinoic acid (ATRA), and the deoxyribonucleic acid polymerase- α inhibitor cytarabine (Ara-C) is now considered for disease-stabilizing treatment of acute myeloid leukemia (AML...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910457/

データ提供:米国国立医学図書館(NLM)

Targeting Leukemia: Exploring the Trifecta of VPA, ATRA, and Ara-C

Acute myeloid leukemia (AML), like a stubborn desert sand dune, can be a difficult cancer to treat. This study investigates the potential of a three-drug combination, including valproic acid (VPA), all-trans retinoic acid (ATRA), and cytarabine (Ara-C), for stabilizing AML. The researchers, like skilled engineers designing a complex system, explore the synergistic effects of these drugs on both leukemia cells and the surrounding bone marrow environment.

A Multi-Pronged Approach: Targeting Leukemia Cells and Their Environment

This study, like a caravan strategically navigating a challenging desert route, explores the potential of a three-drug combination for AML. The researchers, like explorers charting new territory, uncover valuable insights into the complex interactions between leukemia cells and their surrounding environment, paving the way for more effective treatments.

A New Frontier in Leukemia Treatment: Exploring the Potential of Trifecta Therapy

AML, like a stubborn desert sand dune, can be a challenging foe. This study, like a well-equipped expedition, offers hope for individuals facing this disease. The researchers, like skilled guides, explore new avenues for treatment, offering a glimmer of hope for a brighter future.

Dr. Camel's Conclusion

This research, like a well-stocked caravan venturing into the desert of AML, provides valuable insights into the potential of a three-drug combination. The study highlights the importance of targeting both leukemia cells and their surrounding environment for more effective treatment strategies.

Date :
  1. Date Completed 2014-02-14
  2. Date Revised 2021-10-21
Further Info :

Pubmed ID

24527217

DOI: Digital Object Identifier

PMC3910457

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Languages

English

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